User profiles for D. Libri

Domenico Libri

Research Director, CNRS, Institut Jacques Monod, Paris
Verified email at ijm.fr
Cited by 7619

Transcription termination and the control of the transcriptome: why, where and how to stop

O Porrua, D Libri - Nature reviews Molecular cell biology, 2015 - nature.com
Transcription termination occurs when the polymerase is released after a transcription event,
thus delimitating transcription units; however, the functional importance of termination …

[PDF][PDF] Dealing with pervasive transcription

TH Jensen, A Jacquier, D Libri - Molecular cell, 2013 - cell.com
… (D) An lncRNA sponge is depicted as a circle, which was recently demonstrated to
sequester miRNAs efficiently due to its stable nature and the presence of multiple miRNA-binding …

Transcription termination: variations on common themes

O Porrua, M Boudvillain, D Libri - Trends in Genetics, 2016 - cell.com
Transcription initiates pervasively in all organisms, which challenges the notion that the
information to be expressed is selected mainly based on mechanisms defining where and when …

[HTML][HTML] Cryptic pol II transcripts are degraded by a nuclear quality control pathway involving a new poly (A) polymerase

…, B Régnault, F Devaux, A Namane, B Séraphin, D Libri… - Cell, 2005 - cell.com
Since detection of an RNA molecule is the major criterion to define transcriptional activity, the
fraction of the genome that is expressed is generally considered to parallel the complexity …

[HTML][HTML] Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase

…, K Gombert, B Tavitian, V de Franciscis, D Libri - PLoS …, 2005 - journals.plos.org
… Treatment of the cells with the D4 aptamer (Figure 5C), but not with the D4Sc scrambled
control (Figure 5D), significantly decreased the proportion of neurite outgrowth (Figure 5E). To …

[PDF][PDF] Extensive degradation of RNA precursors by the exosome in wild-type cells

…, B Séraphin, LM Steinmetz, A Jacquier, D Libri - Molecular cell, 2012 - cell.com
… In this study, D. melanogaster Dis3p and Rrp6p appear to have distinct roles in degrading
mRNAs, Rrp6p being predominant in targeting NMD substrates (23% of the total Rrp6 targets). …

Interactions between mRNA export commitment, 3′-end quality control, and nuclear degradation

D Libri, K Dower, J Boulay, R Thomsen… - … and cellular biology, 2002 - Taylor & Francis
… (E) Quantitation of the result described for panel D. Signals were normalized to the amount
of U4 RNA and expressed in comparison to the percentage of RNA produced in the rna14-3/…

[PDF][PDF] Transcription termination and nuclear degradation of cryptic unstable transcripts: a role for the nrd1-nab3 pathway in genome surveillance

…, M Rougemaille, J Boulay, D Libri - Molecular cell, 2006 - cell.com
Cryptic unstable transcripts (CUTs) are widely distributed in the genome of S. cerevisiae.
These RNAs generally derive from nonannotated regions of the genome and are degraded …

Yeast homolog of a cancer‐testis antigen defines a new transcription complex

…, L Ilan, K Hofmann, A Namane, C Mann, D Libri - The EMBO …, 2006 - embopress.org
We have isolated a new yeast gene (PCC1) that codes for a factor homologous to human
cancer‐testis antigens. We provide evidence that Pcc1p is a new transcription factor and that …

Phosphorylation of the RNA polymerase II C-terminal domain dictates transcription termination choice

RK Gudipati, T Villa, J Boulay, D Libri - Nature structural & molecular …, 2008 - nature.com
… Growth conditions were as in d. RNAs were digested with RNase H and oligonucleotide
DL163. Failure to polyadenylate HSP104 transcripts in pap1-1 mutants leads to RNA …