User profiles for D. Módos
Dezső MódosQuadram Institute Bioscience Verified email at quadram.ac.uk Cited by 1437 |
[HTML][HTML] Developments in toxicogenomics: understanding and predicting compound-induced toxicity from gene expression data
The toxicogenomics field aims to understand and predict toxicity by using ‘omics’ data in order
to study systems-level responses to compound treatments. In recent years there has been …
to study systems-level responses to compound treatments. In recent years there has been …
Cancer stem cells display extremely large evolvability: alternating plastic and rigid networks as a potential mechanism: network models, novel therapeutic target …
Cancer is increasingly perceived as a systems-level, network phenomenon. The major
trend of malignant transformation can be described as a two-phase process, where an initial …
trend of malignant transformation can be described as a two-phase process, where an initial …
[HTML][HTML] SignaLink 2–a signaling pathway resource with multi-layered regulatory networks
… elegans and D. melanogaster; 2) combines manual curation with large-scale datasets; 3) …
d) An interactive network of first neighbors is available, visualized by the CytoscapeWeb …
d) An interactive network of first neighbors is available, visualized by the CytoscapeWeb …
Integrated intra‐and intercellular signaling knowledge for multicellular omics analysis
Molecular knowledge of biological processes is a cornerstone in omics data analysis. Applied
to single‐cell data, such analyses provide mechanistic insights into individual cells and …
to single‐cell data, such analyses provide mechanistic insights into individual cells and …
[HTML][HTML] The NRF2-related interactome and regulome contain multifunctional proteins and fine-tuned autoregulatory loops
NRF2 is a well-known, master transcription factor (TF) of oxidative and xenobiotic stress
responses. Recent studies uncovered an even wider regulatory role of NRF2 influencing …
responses. Recent studies uncovered an even wider regulatory role of NRF2 influencing …
Autophagy Regulatory Network—A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy
Autophagy is a complex cellular process having multiple roles, depending on tissue,
physiological, or pathological conditions. Major post-translational regulators of autophagy are well …
physiological, or pathological conditions. Major post-translational regulators of autophagy are well …
Adaptation and learning of molecular networks as a description of cancer development at the systems-level: Potential use in anti-cancer therapies
… However, at late stage primary or metastatic tumors, where the underlying network structures
became more asymmetric again (Dezső Módos, Katalin Lenti, Tamás Korcsmáros and …
became more asymmetric again (Dezső Módos, Katalin Lenti, Tamás Korcsmáros and …
SignaLink3: a multi-layered resource to uncover tissue-specific signaling networks
…, B Bohár, M Madgwick, D Módos… - Nucleic acids …, 2022 - academic.oup.com
… SignaLink3 is the largest signaling resource for D. melanogaster with over 1400 unique
proteins and 30 miRNAs. Next to D. melanogaster SignaLink is the only currently available …
proteins and 30 miRNAs. Next to D. melanogaster SignaLink is the only currently available …
[HTML][HTML] NRF2-ome: an integrated web resource to discover protein interaction and regulatory networks of NRF2
NRF2 is the master transcriptional regulator of oxidative and xenobiotic stress responses.
NRF2 has important roles in carcinogenesis, inflammation, and neurodegenerative diseases. …
NRF2 has important roles in carcinogenesis, inflammation, and neurodegenerative diseases. …
[HTML][HTML] Transcriptomics predicts compound synergy in drug and natural product treated glioblastoma cells
LL Pruteanu, L Kopanitsa, D Módos, E Kletnieks… - PLoS …, 2020 - journals.plos.org
Pathway analysis is an informative method for comparing and contrasting drug-induced gene
expression in cellular systems. Here, we define the effects of the marine natural product …
expression in cellular systems. Here, we define the effects of the marine natural product …