Subcellular proteomics

…, CN Betsinger, DG Rattray, D Mahdessian… - Nature Reviews …, 2021 - nature.com
The eukaryotic cell is compartmentalized into subcellular niches, including membrane-bound
and membrane-less organelles. Proteins localize to these niches to fulfil their function, …

A subcellular map of the human proteome

PJ Thul, L Åkesson, M Wiking, D Mahdessian… - Science, 2017 - science.org
INTRODUCTION A complete view of human biology can only be achieved by studying the
molecular components of its smallest functional unit, the cell. Cells are internally organized …

The human secretome

…, J Robinson, B Ayoglu, D Mahdessian, D Sullivan… - Science …, 2019 - science.org
… (D) Chord diagram showing the relationship between the functional annotation of the 730 …
(D) The protein profiles of 86 individuals during a 1-year period were analyzed using a set of …

Spatiotemporal dissection of the cell cycle with single-cell proteogenomics

D Mahdessian, AJ Cesnik, C Gnann, F Danielsson… - Nature, 2021 - nature.com
The cell cycle, over which cells grow and divide, is a fundamental process of life. Its dysregulation
has devastating consequences, including cancer 1 , 2 – 3 . The cell cycle is driven by …

Mapping the nucleolar proteome reveals a spatiotemporal organization related to intrinsic protein disorder

L Stenström, D Mahdessian, C Gnann… - Molecular Systems …, 2020 - embopress.org
The nucleolus is essential for ribosome biogenesis and is involved in many other cellular
functions. We performed a systematic spatiotemporal dissection of the human nucleolar …

[HTML][HTML] Analysis of the human protein atlas weakly supervised single-cell classification competition

…, H Xu, J Mohanakrishnan Kaimal, D Mahdessian… - Nature …, 2022 - nature.com
d, Violin plot of the score distribution per label for the top 50 teams, ordered by decreasing
cell count. n = 50 teams for each violin. The minimum, mean, percentile, and maximum values …

[HTML][HTML] Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells

…, Z Sramkova, A Salašová, H Johard, D Mahdessian… - PLoS …, 2017 - journals.plos.org
The cell cycle coordinates core functions such as replication and cell division. However, cell-cycle-regulated
transcription in the control of non-core functions, such as cell identity …

Spatial characterization of the human centrosome proteome opens up new horizons for a small but versatile organelle

…, D Mahdessian, U Axelsson, D Sullivan… - …, 2020 - Wiley Online Library
After a century of research, the human centrosome continues to fascinate. Based on
immunofluorescence and confocal microscopy, an extensive inventory of the protein components of …

RNA deep sequencing as a tool for selection of cell lines for systematic subcellular localization of all human proteins

F Danielsson, M Wiking, D Mahdessian… - Journal of proteome …, 2013 - ACS Publications
One of the major challenges of a chromosome-centric proteome project is to explore in a
systematic manner the potential proteins identified from the chromosomal genome sequence, …

Author Correction: Spatiotemporal dissection of the cell cycle with single-cell proteogenomics

D Mahdessian, AJ Cesnik, C Gnann… - …, 2022 - pubmed.ncbi.nlm.nih.gov
… Diana Mahdessian … 1 , Manuel D Leonetti …