For a long time, lysosomes were considered merely to be cellular 'incinerators' involved in
the degradation and recycling of cellular waste. However, now there is compelling evidence …

Current hormonal therapies have benefited millions of patients with breast cancer. Their
success, however, is often temporary and limited to a subset of patients whose tumors express …

… Some lines, such as COMMA-1D, FSK4, and TMI2 show extensive growth potential in
vivo even after 20 passages in vitro (Medina, unpublished observations). The reason that …

… S3, A to D). This increase persisted in cells treated with bafilomycin and pepstatin, as well as
the … (D) TFEB mRNA levels from cells transfected with siRNA oligomers targeting TFEB or a …

Progress toward understanding the biology of prostate cancer has been slow due to the few
animal research models available to study the spectrum of this uniquely human disease. To …

Lysosomes are organelles central to degradation and recycling processes in animal cells.
Whether lysosomal activity is coordinated to respond to cellular needs remains unclear. We …

… (D) Immunoblotting of proteins extracted from HeLa cells that express TFEB–3 × FLAG
treated with DMSO, chloroquine (CQ) or SalA, subjected to nuclear/cytosolic fractionation and …

The view of the lysosome as the terminal end of cellular catabolic pathways has been challenged
by recent studies showing a central role of this organelle in the control of cell function. …

… After 24 h, hMSCs preexposed to TCM for 1 to 30 d were added (25,000 … 30 d (25,000 per
well), and hMSCs were differentiated to myogenic lineage by 5-aza (25,000 per well). After 4 d, …

Purpose: To guide treatment planning by analyzing the rates of dental implant failure to
determine associated risk factors. Materials and Methods: All consecutively treated patients from …