The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells
D Metcalf - Nature, 1989 - nature.com
Several glycoproteins that control blood-cell production and function have been purified and
sequenced. The four colony-stimulating factors interact in a complex way to regulate the …
sequenced. The four colony-stimulating factors interact in a complex way to regulate the …
The granulocyte-macrophage colony-stimulating factors
D Metcalf - Science, 1985 - science.org
… NA Nicola and D. Metcalf, Proc. Natl. Acad. … Metcalf and NA Nicola, in Molecular
Biology of Tumor Cells, B. Wahrenet al., Eds. (Raven, New York, 1985), pp. …
Biology of Tumor Cells, B. Wahrenet al., Eds. (Raven, New York, 1985), pp. …
The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors
D Metcalf - 1986 - ashpublications.org
Rapid progress has occurred recently in characterizing the molecular nature of the specific
glycoprotein colony-stimulating factors (CSFs) controlling the proliferation; and some …
glycoprotein colony-stimulating factors (CSFs) controlling the proliferation; and some …
THE GROWTH OF MOUSE BONE MARROW CELLS IN VITRO
TR Bradley, D Metcalf - Australian Journal of Experimental …, 1966 - Wiley Online Library
A simple in vitro technique is described for the growth of colonies from single cell suspensions
of mouse bone marrow. The system involves the plating of marrow cells in agar on feeder …
of mouse bone marrow. The system involves the plating of marrow cells in agar on feeder …
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells
…, CL Stewart, DP Gearing, EF Wagner, D Metcalf… - Nature, 1988 - nature.com
Embryonic stem (ES) cells, the totipotent outgrowths of bias-tocysts 1,2 , can be cultured and
manipulated in vitro and then returned to the embryonic environment where they develop …
manipulated in vitro and then returned to the embryonic environment where they develop …
[HTML][HTML] A family of cytokine-inducible inhibitors of signalling
…, BJ Jenkins, TJ Gonda, WS Alexander, D Metcalf… - Nature, 1997 - nature.com
Cytokines are secreted proteins that regulate important cellular responses such as
proliferation and differentiation 1 . Key events in cytokine signal transduction are well defined: …
proliferation and differentiation 1 . Key events in cytokine signal transduction are well defined: …
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
P Bouillet, D Metcalf, DCS Huang, DM Tarlinton… - Science, 1999 - science.org
Apoptosis can be triggered by members of the Bcl-2 protein family, such as Bim, that share
only the BH3 domain with this family. Gene targeting in mice revealed important physiological …
only the BH3 domain with this family. Gene targeting in mice revealed important physiological …
[HTML][HTML] Abnormalities of the left temporal lobe and thought disorder in schizophrenia: a quantitative magnetic resonance imaging study
…, CG Wible, H Hokama, J Martin, D Metcalf… - … England Journal of …, 1992 - Mass Medical Soc
Background. Data from postmortem, CT, and magnetic resonance imaging (MRI) studies
indicate that patients with schizophrenia may have anatomical abnormalities of the left temporal …
indicate that patients with schizophrenia may have anatomical abnormalities of the left temporal …
[HTML][HTML] Programmed anuclear cell death delimits platelet life span
…, AA Hilton, S Ellis, PN Kelly, PG Ekert, D Metcalf… - Cell, 2007 - cell.com
Platelets are anuclear cytoplasmic fragments essential for blood clotting and wound healing.
Despite much speculation, the factors determining their life span in the circulation are …
Despite much speculation, the factors determining their life span in the circulation are …
Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology.
…, GJ Lieschke, D Grail, D Metcalf… - Proceedings of the …, 1994 - National Acad Sciences
Mice homozygous for a disrupted granulocyte/macrophage colony-stimulating factor (GM-CSF)
gene develop normally and show no major perturbation of hematopoiesis up to 12 weeks …
gene develop normally and show no major perturbation of hematopoiesis up to 12 weeks …