User profiles for D. Michieletto

Davide Michieletto

Royal Society University Research Fellow, University of Edinburgh
Verified email at ed.ac.uk
Cited by 1840

Rheology and viscoelasticity of proteins and nucleic acids condensates

D Michieletto, M Marenda - JACS Au, 2022 - ACS Publications
D and d = 1, 2, or 3 being the dimensionality of the tracked trajectory r(τ). For passive spherical
tracers, the Stokes–Einstein relation connects the diffusion coefficient of the tracers D to …

[HTML][HTML] Role of nuclear RNA in regulating chromatin structure and transcription

D Michieletto, N Gilbert - Current opinion in cell biology, 2019 - Elsevier
… can stabilise a state in which proteins form micro-phase separated aggregates, ie a multitude
of non-growing droplets with finite size and made of ever-recycling components (Figure 2d)…

Bridging-induced phase separation induced by cohesin SMC protein complexes

…, AJ Katan, A Bonato, D Marenduzzo, D Michieletto… - Science …, 2021 - science.org
… (A to D) Representative AFM images of cohesin holocomplex as it binds to different DNA
lengths of 100 bp, 3 kbp, 5 kbp, and 48.5 kbp, respectively. (E) Radius of gyration of cohesin-…

Polymer model with Epigenetic Recoloring Reveals a Pathway for the de novo Establishment and 3D Organization of Chromatin Domains

D Michieletto, E Orlandini, D Marenduzzo - Physical Review X, 2016 - APS
One of the most important problems in development is how epigenetic domains can first be
established, and then maintained, within cells. To address this question, we propose a …

Nonequilibrium chromosome looping via molecular slip links

CA Brackley, J Johnson, D Michieletto, AN Morozov… - Physical review …, 2017 - APS
… For a single slip link, we need D = D0C 2 > 10 kbp2 =s; for multiple slip links due to the
ratchet effect a substantially smaller D suffices. The worst-case scenario occurs for the least …

[HTML][HTML] Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction

JM Eeftens, M Kapoor, D Michieletto… - Nature …, 2021 - nature.com
d Recruitment data suggest that RNF2 is the central node in the PRC1 complex. Width of
grey bars represents relative recruitment strength (average of the two PCC scores). e …

A topologically driven glass in ring polymers

D Michieletto, MS Turner - Proceedings of the National …, 2016 - National Acad Sciences
… if its distance from a monomer j belonging to a different chain J is d i j < ρ − 1 / 3 where ρ =
0.1 σ − … The critical value c † is defined as the one for which D eff ( c † ) / D 0 is below a critical …

ParB proteins can bypass DNA-bound roadblocks via dimer-dimer recruitment

…, B Pradhan, A Barth, J van der Torre, D Michieletto… - Science …, 2022 - science.org
… (D) Histogram showing loading position of ParB dimers along DNA parS . The position of
parS site is represented by dashed lines (n = 168). (E) Residence times of diffusing ParB dimer …

[HTML][HTML] Ring polymers: Threadings, knot electrophoresis and topological glasses

D Michieletto, D Marenduzzo, E Orlandini, MS Turner - Polymers, 2017 - mdpi.com
… In the phase diagrams in Figure 8B,D, we also shown the “critical” line fitted by the expressions
in Equations (6) and (7). We highlight here that Equations (6) and (7) describe the same …

[PDF][PDF] Ephemeral protein binding to DNA shapes stable nuclear bodies and chromatin domains

…, D Michieletto, F Mouvet, PR Cook, D Marenduzzo - Biophysical journal, 2017 - cell.com
… cc and Φ0 = Aφ exp (iqcx)+cc with amplitudes A, Aφ, we find qc = (D/A)1/4 reproducing
the corresponding result from our linear stability analysis (see above), as well as Aφ = A(D +Aq2 …