User profiles for D. Moi

Davide Moi

- Verified email at unimore.it - Cited by 537

David Moi

- Verified email at unil.ch - Cited by 367

[HTML][HTML] Recent advances in SARS-CoV-2 main protease inhibitors: from nirmatrelvir to future perspectives

A Citarella, A Dimasi, D Moi, D Passarella, A Scala… - Biomolecules, 2023 - mdpi.com
… These compounds have been shown to have a high binding affinity toward M pro , comparable
to that of Nirmatrelvir (K d values of 26 nM and 30 nM for 12 and 13, respectively, and 7 …

Hydroxamic acid derivatives: From synthetic strategies to medicinal chemistry applications

A Citarella, D Moi, L Pinzi, D Bonanni, G Rastelli - ACS omega, 2021 - ACS Publications
… (21) HA derivatives have also been reported to target DXR (1-deoxy-d-xylulose 5-… it converts
DXP (1-deoxy-d-xylulose 5-phosphate) to MEP (2-C-methyl-d-erythritol-4-phosphate) has …

Targeted genome editing in human repopulating haematopoietic stem cells

…, G Escobar, T Di Tomaso, C Firrito, A Calabria, D Moi… - Nature, 2014 - nature.com
… of the corrective cDNA on cells from c and d. f, Expression of the fusion transcript bearing …
We thank D. Weissman for advice on mRNA production and the whole Naldini laboratory for …

[PDF][PDF] Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells

R Mazzieri, F Pucci, D Moi, E Zonari, A Ranghetti… - Cancer cell, 2011 - cell.com
Tumor-infiltrating myeloid cells convey proangiogenic programs that counteract the efficacy
of antiangiogenic therapy. Here, we show that blocking angiopoietin-2 (ANG2), a TIE2 ligand …

A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood “resident” monocytes, and embryonic macrophages suggests common …

…, MA Venneri, D Biziato, A Nonis, D Moi… - Blood, The Journal …, 2009 - ashpublications.org
We previously showed that Tie2-expressing monocytes (TEMs) have nonredundant
proangiogenic activity in tumors. Here, we compared the gene expression profile of tumor-infiltrating …

[PDF][PDF] Tumor-targeted interferon-α delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis

…, F Pucci, E Zonari, G Sitia, S Mazzoleni, D Moi… - Cancer cell, 2008 - cell.com
The use of type I interferons (IFNs) in cancer therapy has been limited by ineffective dosing
and significant toxicity. Here, we exploited the tumor-homing ability of proangiogenic Tie2-…

Intermediate disturbance hypothesis in ecology: a literature review

DA Moi, R García-Ríos, Z Hong, BV Daquila… - Annales Zoologici …, 2020 - BioOne
… Annual citations of an article in which the IDH was (C) supported and (D) not supported
depending on the impact factor of the journal in which the article ws published. …

[PDF][PDF] miR-511-3p modulates genetic programs of tumor-associated macrophages

ML Squadrito, F Pucci, L Magri, D Moi, GD Gilfillan… - Cell reports, 2012 - cell.com
Expression of the mannose receptor (MRC1/CD206) identifies macrophage subtypes, such
as alternatively activated macrophages (AAMs) and M2-polarized tumor-associated …

OMA orthology in 2021: website overhaul, conserved isoforms, ancestral gene order and more

…, I Mediratta, T Mendes de Farias, D Moi… - Nucleic acids …, 2021 - academic.oup.com
OMA is an established resource to elucidate evolutionary relationships among genes from
currently 2326 genomes covering all domains of life. OMA provides pairwise and groupwise …

Engineering a humanized bone organ model in mice to study bone metastases

…, TD Brown, B Nowlan, DJ Wu, CO Hutmacher, D Moi… - Nature protocols, 2017 - nature.com
Current in vivo models for investigating human primary bone tumors and cancer metastasis
to the bone rely on the injection of human cancer cells into the mouse skeleton. This …