[HTML][HTML] Recent advances in SARS-CoV-2 main protease inhibitors: from nirmatrelvir to future perspectives
A Citarella, A Dimasi, D Moi, D Passarella, A Scala… - Biomolecules, 2023 - mdpi.com
… These compounds have been shown to have a high binding affinity toward M pro , comparable
to that of Nirmatrelvir (K d values of 26 nM and 30 nM for 12 and 13, respectively, and 7 …
to that of Nirmatrelvir (K d values of 26 nM and 30 nM for 12 and 13, respectively, and 7 …
Hydroxamic acid derivatives: From synthetic strategies to medicinal chemistry applications
… (21) HA derivatives have also been reported to target DXR (1-deoxy-d-xylulose 5-… it converts
DXP (1-deoxy-d-xylulose 5-phosphate) to MEP (2-C-methyl-d-erythritol-4-phosphate) has …
DXP (1-deoxy-d-xylulose 5-phosphate) to MEP (2-C-methyl-d-erythritol-4-phosphate) has …
Targeted genome editing in human repopulating haematopoietic stem cells
…, G Escobar, T Di Tomaso, C Firrito, A Calabria, D Moi… - Nature, 2014 - nature.com
… of the corrective cDNA on cells from c and d. f, Expression of the fusion transcript bearing …
We thank D. Weissman for advice on mRNA production and the whole Naldini laboratory for …
We thank D. Weissman for advice on mRNA production and the whole Naldini laboratory for …
[PDF][PDF] Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells
R Mazzieri, F Pucci, D Moi, E Zonari, A Ranghetti… - Cancer cell, 2011 - cell.com
Tumor-infiltrating myeloid cells convey proangiogenic programs that counteract the efficacy
of antiangiogenic therapy. Here, we show that blocking angiopoietin-2 (ANG2), a TIE2 ligand …
of antiangiogenic therapy. Here, we show that blocking angiopoietin-2 (ANG2), a TIE2 ligand …
A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood “resident” monocytes, and embryonic macrophages suggests common …
…, MA Venneri, D Biziato, A Nonis, D Moi… - Blood, The Journal …, 2009 - ashpublications.org
We previously showed that Tie2-expressing monocytes (TEMs) have nonredundant
proangiogenic activity in tumors. Here, we compared the gene expression profile of tumor-infiltrating …
proangiogenic activity in tumors. Here, we compared the gene expression profile of tumor-infiltrating …
[PDF][PDF] Tumor-targeted interferon-α delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis
The use of type I interferons (IFNs) in cancer therapy has been limited by ineffective dosing
and significant toxicity. Here, we exploited the tumor-homing ability of proangiogenic Tie2-…
and significant toxicity. Here, we exploited the tumor-homing ability of proangiogenic Tie2-…
Intermediate disturbance hypothesis in ecology: a literature review
DA Moi, R García-Ríos, Z Hong, BV Daquila… - Annales Zoologici …, 2020 - BioOne
… Annual citations of an article in which the IDH was (C) supported and (D) not supported
depending on the impact factor of the journal in which the article ws published. …
depending on the impact factor of the journal in which the article ws published. …
[PDF][PDF] miR-511-3p modulates genetic programs of tumor-associated macrophages
Expression of the mannose receptor (MRC1/CD206) identifies macrophage subtypes, such
as alternatively activated macrophages (AAMs) and M2-polarized tumor-associated …
as alternatively activated macrophages (AAMs) and M2-polarized tumor-associated …
OMA orthology in 2021: website overhaul, conserved isoforms, ancestral gene order and more
OMA is an established resource to elucidate evolutionary relationships among genes from
currently 2326 genomes covering all domains of life. OMA provides pairwise and groupwise …
currently 2326 genomes covering all domains of life. OMA provides pairwise and groupwise …
Engineering a humanized bone organ model in mice to study bone metastases
Current in vivo models for investigating human primary bone tumors and cancer metastasis
to the bone rely on the injection of human cancer cells into the mouse skeleton. This …
to the bone rely on the injection of human cancer cells into the mouse skeleton. This …