BACKGROUND The aberrant activation of the PI3K/mTOR signaling circuitry is one of the
most frequently dysregulated signaling events in head and neck squamous cell carcinoma (…

… (C and D) Each spot on the 2D surface represents one of the 1,179 coding positions in
TP53. The y axis indicates mutant allele frequency (MAF). By standard NGS, all positions show …

Next-generation sequencing methods suffer from low recovery, uneven coverage, and false
mutations. DNA fragmentation by sonication is a major contributor to these problems …

Microenvironmental and molecular factors mediating the progression of Breast Ductal
Carcinoma In Situ (DCIS) are not well understood, impeding the development of prevention …

… To further investigate the mutational pattern by biopsy type within the D-loop and non–D-loop
region, we separated transitions and transversions into the corresponding nucleotide …

… Western immunoblotting demonstrated that the a isoform is much more abundant than g/d
in the hippocampus (Figure 1B) as well as other brain regions (Figure 1—figure supplement 1)…

G proteins and G protein–coupled receptors activate a diverse array of signal transduction
pathways that promote cell growth and survival. Indeed, hot spot–activating mutations in …

… , and liver tissues at 3 h, 24 h, 7 d, and 28 d post-exposure. Significant increases in MF were
… 7 d for liver and blood. The canonical, mutational signature of ENU was established by 7 d …

… d Evaluation of discrimination of Cox proportional hazard model for BCSE vs no BCSE
outcome using Harrel’s C-index (y-axis) for models only using available risk factors versus …

Objective Pap tests hold promise as a molecular diagnostic for serous ovarian cancer, but
previous studies reported limited sensitivity. Furthermore, the presence of somatic mutations in …