[HTML][HTML] The exosome journey: from biogenesis to uptake and intracellular signalling
S Gurung, D Perocheau, L Touramanidou… - Cell Communication and …, 2021 - Springer
The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials
testing exosomes for diagnostic and therapeutic applications are generating remarkable …
testing exosomes for diagnostic and therapeutic applications are generating remarkable …
Clinical applications for exosomes: Are we there yet?
D Perocheau, L Touramanidou… - British journal of …, 2021 - Wiley Online Library
Exosomes are a subset of extracellular vesicles essential for cell–cell communication in
health and disease with the ability to transport nucleic acids, functional proteins and other …
health and disease with the ability to transport nucleic acids, functional proteins and other …
IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production
…, HL Eames, M Weiss, AJ Byrne, D Perocheau… - Journal of Experimental …, 2015 - rupress.org
… Using a wide range of doses (0.004–4 mg/kg/d), we demonstrated that … kg/d, as shown by
overall clinical score (unpublished data). In all subsequent experiments, we used a 0.4 mg/kg/d …
overall clinical score (unpublished data). In all subsequent experiments, we used a 0.4 mg/kg/d …
Fetal gene therapy for neurodegenerative disease of infants
…, BR Herbert, S Karlsson, DP Perocheau, D Burke… - Nature medicine, 2018 - nature.com
For inherited genetic diseases, fetal gene therapy offers the potential of prophylaxis against
early, irreversible and lethal pathological change. To explore this, we studied neuronopathic …
early, irreversible and lethal pathological change. To explore this, we studied neuronopathic …
IRF5 controls both acute and chronic inflammation
… IRF5 deficient mice (IRF5 −/− ) and their littermate wild-type controls (WT) were immunized
with mBSA in CFA and 7 d later, knees were either challenged with mBSA or PBS control (Fig…
with mBSA in CFA and 7 d later, knees were either challenged with mBSA or PBS control (Fig…
[HTML][HTML] IRF5 Is a Specific Marker of Inflammatory Macrophages In Vivo
Macrophages are an integral part of the innate immune system and key players in pathogen
clearance and tissue remodelling. Both functions are accomplished by a pivotal network of …
clearance and tissue remodelling. Both functions are accomplished by a pivotal network of …
[HTML][HTML] Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates …
…, AC Palfreeman, M Andrews, DP Perocheau… - Arthritis research & …, 2010 - Springer
… with 25 mg/kg apremilast is shown in (d). Asterisk shows inflammation of the synovial
membrane, … (d) All sections were scored for the extent of inflammation and damage, and graded …
membrane, … (d) All sections were scored for the extent of inflammation and damage, and graded …
Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen‐induced …
FE McCann, DP Perocheau, G Ruspi… - Arthritis & …, 2014 - Wiley Online Library
… d, Schematic diagram of our proposed model of acute inflammation. As shown at the left,
anti-TNF blocks signaling via TNFRI (R1) and TNFRII (R2), which results not only in reduced …
anti-TNF blocks signaling via TNFRI (R1) and TNFRII (R2), which results not only in reduced …
[HTML][HTML] Gene therapy for inherited metabolic diseases
BS Yilmaz, S Gurung, D Perocheau… - Journal of Mother and …, 2020 - sciendo.com
… This was followed by a multicentre, phase II/III clinical trial conducted by BlueBird Bio (NCT01896102)
with a vector Lenti-D similar to the one used in treating the first two patients. …
with a vector Lenti-D similar to the one used in treating the first two patients. …
[HTML][HTML] Ascending vaginal infection using bioluminescent bacteria evokes intrauterine inflammation, preterm birth, and neonatal brain injury in pregnant mice
…, JA Diaz, J Ng, J Baruteau, D Perocheau… - The American journal of …, 2018 - Elsevier
… D–F: Time to delivery (D), the proportion of pups born alive (E), and litter size (F) were
determined in dams who received intravaginal phosphate-buffered saline (PBS) or intravaginal E. …
determined in dams who received intravaginal phosphate-buffered saline (PBS) or intravaginal E. …