Epigenetic refers to a range of heritable chromatin modifications including DNA methylation,
histone modifications, remodeling of nucleosomes and higher order chromatin modifications…

… Quenet and Dalal have now discovered that an RNA polymerase localizes to the DNA in
human centromeres and produces RNA molecules during the early stages of the cell cycle. …

In eukaryotes, DNA is packaged into chromatin by canonical histone proteins. The specialized
histone H3 variant CENP-A provides an epigenetic and structural basis for chromosome …

The centromere is a specialized locus that directs the formation of the kinetochore protein
complex for correct chromosome segregation. The specific centromere histone H3 variant …

Besides the established central role of poly(ADP-ribose) polymerase-1 (Parp-1) and Parp-2
in the maintenance of genomic integrity, accumulating evidence indicates that poly(ADP-…

In eukaryotes, the genome is organized into a complex nucleoprotein structure called
chromatin. Despite the simplicity of its monomer, DNA and two copies of four histones, the …

Recent advances reveal emerging unique functions of poly(ADP‐ribose) polymerase‐1 (Parp‐1)
and Parp‐2 in heterochromatin integrity and cell differentiation. However, the chromatin…

Poly(ADP-ribose) polymerase 1 (PARP1, also known as ARTD1) is an abundant nuclear
enzyme that plays important roles in DNA repair, gene transcription, and differentiation through …

The established view that chromatin is compacted into 30 nm fibres in the nucleus is being
challenged. One of these studies is published in this issue of EMBO reports and shows that …

… Pour répondre à ce problème récurrent d’identification et de visibilité, le projet ANR Kindunos
(responsable G. Quenet) est en train de construire une base de données bibliographique …