Mapping brain asymmetry in health and disease through the ENIGMA consortium

…, SR Mathias, D Van Rooij, D Schijven… - Human brain …, 2022 - Wiley Online Library
… Cohen's d effect sizes of the associations between disorder diagnosis and AIs. The d values
are overlaid on the left hemisphere for visualization. Positive Cohen's d values (red) indicate …

[HTML][HTML] International meta-analysis of PTSD genome-wide association studies identifies sex-and ancestry-specific genetic risk loci

…, NL Saccone, SE Sanchez, D Schijven… - Nature …, 2019 - nature.com
The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust
common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD …

[HTML][HTML] Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

RL McLaughlin, D Schijven, W Van Rheenen… - Nature …, 2017 - nature.com
We have previously shown higher-than-expected rates of schizophrenia in relatives of patients
with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between …

[HTML][HTML] The genetic architecture of structural left–right asymmetry of the human brain

Z Sha, D Schijven, A Carrion-Castillo, M Joliot… - Nature human …, 2021 - nature.com
… Life on Earth is based on L-form amino acids rather than the mirror D-form, and this chirality
carries through to the macrostructure and movement of primary cilia 25,26 , which help to …

[HTML][HTML] Enhancing discovery of genetic variants for posttraumatic stress disorder through integration of quantitative phenotypes and trauma exposure information

…, BPF Rutten, NL Saccone, SE Sanchez, D Schijven… - Biological …, 2022 - Elsevier
Background Posttraumatic stress disorder (PTSD) is heritable and a potential consequence
of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD …

Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium

D Schijven, MC Postema… - Proceedings of the …, 2023 - National Acad Sciences
Left–right asymmetry is an important organizing feature of the healthy brain that may be
altered in schizophrenia, but most studies have used relatively small samples and …

Genetic architecture of the white matter connectome of the human brain

Z Sha, D Schijven, SE Fisher, C Francks - Science advances, 2023 - science.org
… (C and D) On the basis of BrainSpan data from 11 life-span stages or 29 age groups,
genes associated with variation in (C) adult node-level connectivity and (D) adult edge-level …

[HTML][HTML] Patterns of brain asymmetry associated with polygenic risks for autism and schizophrenia implicate language and executive functions but not brain …

Z Sha, D Schijven, C Francks - Molecular psychiatry, 2021 - nature.com
Autism spectrum disorder (ASD) and schizophrenia have been conceived as partly opposing
disorders in terms of systemizing vs. empathizing cognitive styles, with resemblances to …

Handedness and its genetic influences are associated with structural asymmetries of the cerebral cortex in 31,864 individuals

Z Sha, A Pepe, D Schijven… - Proceedings of the …, 2021 - National Acad Sciences
Roughly 10% of the human population is left-handed, and this rate is increased in some
brain-related disorders. The neuroanatomical correlates of hand preference have remained …

Comprehensive pathway analyses of schizophrenia risk loci point to dysfunctional postsynaptic signaling

D Schijven, D Kofink, V Tragante, M Verkerke… - Schizophrenia …, 2018 - Elsevier
… (A) mapped SNPs to genes, (B) calculated gene p-values based on GWAS SNP p-values,
(C) performed a primary gene set enrichment analysis using gene ontology (GO) terms, and (D