Rotaviruses are the leading etiological agents of acute gastroenteritis in infants and young
children worldwide. These nonenveloped viruses enter cells using different types of …

Rotavirus (RV) is the major cause of childhood gastroenteritis worldwide. This study presents
a functional genome-scale analysis of cellular proteins and pathways relevant for RV …

Several molecules have been identified as receptors or coreceptors for rotavirus infection,
including glycans, integrins, and hsc70. In this work we report that the tight junction proteins …

Rotaviruses (RVs) enter cells through different endocytic pathways. Bovine rotavirus (BRV)
UK uses clathrin-mediated endocytosis, while rhesus rotavirus (RRV) employs an endocytic …

Nanoparticles coated with natural cell membranes have emerged as a promising class of
biomimetic nanomedicine with significant clinical potential. Among them, macrophage …

Here we show that the ubiquitin-proteasome system is required for the efficient replication of
rotavirus RRV in MA104 cells. The proteasome inhibitor MG132 decreased the yield of …

10.7554/eLife.42906.001 Rotavirus genome replication and assembly take place in
cytoplasmic electron dense inclusions termed viroplasms (VPs). Previous conventional optical …

… (C and D) Electron micrographs of MA104 cells that were left untreated (C) or treated with
0.5 μM JAS (D) for 4 h at 37C. Cells were fixed and embedded as described in Materials and …

Cellular and viral factors participate in the replication cycle of rotavirus. We report that the
guanine nucleotide exchange factor GBF1, which activates the small GTPase Arf1 to induce …

… signaling pathway, such as Cdc42-WASP-Arp2/3, could be involved in this process, especially
since the WASP protein was found to also facilitate rotavirus infection (Silva-Ayala et al., …