User profiles for D. Van Ly
 | David Van LyPostdoctoral Research Officer, The Children's Medical Research Institute Verified email at cmri.org.au Cited by 554 |
Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress
Filamentous actin (F-actin) provides cells with mechanical support and promotes the mobility
of intracellular structures. Although F-actin is traditionally considered to be cytoplasmic, …
of intracellular structures. Although F-actin is traditionally considered to be cytoplasmic, …
[PDF][PDF] Telomere loop dynamics in chromosome end protection
… Van Ly et al. identify that telomere loops (t-loops) function as conformational switches
that regulate ATM activity at chromosome ends. They find ATM activity is suppressed when …
that regulate ATM activity at chromosome ends. They find ATM activity is suppressed when …
CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle
… d, Western blot of input and RTEL1 immunoprecipitates from extracts of HEK 293 cells
expressing Myc–TRF2 and pre-treated with vehicle, PLK1 inhibitor (PLK1i) or CDK inhibitor R-…
expressing Myc–TRF2 and pre-treated with vehicle, PLK1 inhibitor (PLK1i) or CDK inhibitor R-…
TRF2-independent chromosome end protection during pluripotency
… d, Flow cytometry determination of DNA content for the indicated cells 96 h after OHT or
EtOH treatment. n = 3, ≥10,000 cells per condition. e, f, Images and quantification of telomere-…
EtOH treatment. n = 3, ≥10,000 cells per condition. e, f, Images and quantification of telomere-…
Differential neutrophil activation in viral infections: Enhanced TLR‐7/8‐mediated CXCL 8 release in asthma
… David Van Ly … David Van Ly … one or more of the three normality tests provided (Kolmogorov–Smirnov,
D'Agostino and Pearson and Shapiro–Wilk normality tests; GraphPad Prism 5, La …
D'Agostino and Pearson and Shapiro–Wilk normality tests; GraphPad Prism 5, La …
[HTML][HTML] Characterising the Mechanism of Airway Smooth Muscle β2 Adrenoceptor Desensitization by Rhinovirus Infected Bronchial Epithelial Cells
Rhinovirus (RV) infections account for approximately two thirds of all virus-induced asthma
exacerbations and often result in an impaired response to β 2 agonist therapy. Using an in …
exacerbations and often result in an impaired response to β 2 agonist therapy. Using an in …
BET proteins are associated with the induction of small airway fibrosis in COPD
… David Van Ly5, … Data were analysed by Friedman test and Wilcoxon Sign Ranked post-hoc
analysis (* denotes p<0.05 from relevant control, unless otherwise indicated; (D) significant …
analysis (* denotes p<0.05 from relevant control, unless otherwise indicated; (D) significant …
Prostaglandins but not leukotrienes alter extracellular matrix protein deposition and cytokine release in primary human airway smooth muscle cells and fibroblasts
D Van Ly, JK Burgess, TG Brock… - … of Physiology-Lung …, 2012 - journals.physiology.org
… Furthermore, in vitro studies have shown that leukotriene (LT) D 4 can increase TnC and
laminin β 2 in the cell line BEAS-2Bs and increase ASM proliferation in the presence of …
laminin β 2 in the cell line BEAS-2Bs and increase ASM proliferation in the presence of …
[HTML][HTML] Effects of β Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway …
… Correspondence should be addressed to David Van Ly, dvan7422@usyd.edu.au … Copyright
© 2011 David Van Ly et al. This is an open access article distributed under the Creative …
© 2011 David Van Ly et al. This is an open access article distributed under the Creative …
Antitumor cytotoxicity induced by bone-marrow-derived antigen-presenting cells is facilitated by the tumor suppressor protein p53 via regulation of IL-12
…, HG Campbell, VK Ward, VL Young, D Van Ly… - …, 2016 - Taylor & Francis
… unvaccinated control animals 60 d post tumor cell administration (… group where none survived
beyond 40 d). However, when … at 60 d post tumor implantation (median survival 25 d, p = …
beyond 40 d). However, when … at 60 d post tumor implantation (median survival 25 d, p = …