User profiles for D. Vorselen

Daan Vorselen

Assistant professor
Verified email at wur.nl
Cited by 1739

The role of the cytoskeleton in sensing changes in gravity by nonspecialized cells

D Vorselen, WH Roos, FC MacKintosh… - The FASEB …, 2014 - Wiley Online Library
A large body of evidence indicates that single cells in vitro respond to changes in gravity, and
that this response might play an important role for physiological changes at the organism …

Generic indicators for loss of resilience before a tipping point leading to population collapse

L Dai, D Vorselen, KS Korolev, J Gore - Science, 2012 - science.org
Theory predicts that the approach of catastrophic thresholds in natural systems (eg,
ecosystems, the climate) may result in an increasingly slow recovery from small perturbations, a …

[HTML][HTML] A mechanical perspective on phagocytic cup formation

D Vorselen, RLD Labitigan, JA Theriot - Current opinion in cell biology, 2020 - Elsevier
Phagocytosis is a widespread and evolutionarily conserved process with diverse biological
functions, ranging from engulfment of invading microbes during infection to clearance of …

Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens

…, RA Kamber, H Collins, A Tucker, A Li, D Vorselen… - Nature …, 2018 - nature.com
… At 3 d after infection we selected with 1 μg ml –1 puromycin for U937s and 10 μg ml –1
puromycin for RAW 264.7 cells for 5 d. In cases where single-cell clonal knockout lines were …

Dynamics of phagocytosis mediated by phosphatidylserine

D Vorselen - Biochemical Society Transactions, 2022 - portlandpress.com
Phagocytosis triggered by the phospholipid phosphatidylserine (PS) is key for the removal
of apoptotic cells in development, tissue homeostasis and infection. Modulation of PS-…

[HTML][HTML] Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell–target interactions

D Vorselen, Y Wang, MM de Jesus, PK Shah… - Nature …, 2020 - nature.com
d Spherical harmonic power spectrum indicating the power of the distance to the centroid
over the particle surface per degree l (summed over orders m) for 7 particles; colors indicate …

[HTML][HTML] Alba shapes the archaeal genome using a delicate balance of bridging and stiffening the DNA

N Laurens, RPC Driessen, I Heller, D Vorselen… - Nature …, 2012 - nature.com
… the DNA stiffness, the measured FD curve will be a linear combination of a FD curve of a
saturated DNA molecule (d saturated (F)) and a FD curve of a bare DNA molecule (d bare (F)). …

[HTML][HTML] The fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis

D Vorselen, SM van Dommelen, R Sorkin… - Nature …, 2018 - nature.com
Extracellular vesicles (EVs) are widely studied regarding their role in cell-to-cell communication
and disease, as well as for applications as biomarkers or drug delivery vehicles. EVs …

Competition between bending and internal pressure governs the mechanics of fluid nanovesicles

D Vorselen, FC MacKintosh, WH Roos, GJL Wuite - ACS nano, 2017 - ACS Publications
Nanovesicles (∼100 nm) are ubiquitous in cell biology and an important vector for drug
delivery. Mechanical properties of vesicles are known to influence cellular uptake, but the …

Phagocytic 'teeth'and myosin-II 'jaw'power target constriction during phagocytosis

D Vorselen, SR Barger, Y Wang, W Cai, JA Theriot… - Elife, 2021 - elifesciences.org
Phagocytosis requires rapid actin reorganization and spatially controlled force generation to
ingest targets ranging from pathogens to apoptotic cells. How actomyosin activity directs …