User profiles for D. Vorselen
Daan VorselenAssistant professor Verified email at wur.nl Cited by 1739 |
The role of the cytoskeleton in sensing changes in gravity by nonspecialized cells
A large body of evidence indicates that single cells in vitro respond to changes in gravity, and
that this response might play an important role for physiological changes at the organism …
that this response might play an important role for physiological changes at the organism …
Generic indicators for loss of resilience before a tipping point leading to population collapse
Theory predicts that the approach of catastrophic thresholds in natural systems (eg,
ecosystems, the climate) may result in an increasingly slow recovery from small perturbations, a …
ecosystems, the climate) may result in an increasingly slow recovery from small perturbations, a …
[HTML][HTML] A mechanical perspective on phagocytic cup formation
D Vorselen, RLD Labitigan, JA Theriot - Current opinion in cell biology, 2020 - Elsevier
Phagocytosis is a widespread and evolutionarily conserved process with diverse biological
functions, ranging from engulfment of invading microbes during infection to clearance of …
functions, ranging from engulfment of invading microbes during infection to clearance of …
Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens
…, RA Kamber, H Collins, A Tucker, A Li, D Vorselen… - Nature …, 2018 - nature.com
… At 3 d after infection we selected with 1 μg ml –1 puromycin for U937s and 10 μg ml –1
puromycin for RAW 264.7 cells for 5 d. In cases where single-cell clonal knockout lines were …
puromycin for RAW 264.7 cells for 5 d. In cases where single-cell clonal knockout lines were …
Dynamics of phagocytosis mediated by phosphatidylserine
D Vorselen - Biochemical Society Transactions, 2022 - portlandpress.com
Phagocytosis triggered by the phospholipid phosphatidylserine (PS) is key for the removal
of apoptotic cells in development, tissue homeostasis and infection. Modulation of PS-…
of apoptotic cells in development, tissue homeostasis and infection. Modulation of PS-…
[HTML][HTML] Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell–target interactions
… d Spherical harmonic power spectrum indicating the power of the distance to the centroid
over the particle surface per degree l (summed over orders m) for 7 particles; colors indicate …
over the particle surface per degree l (summed over orders m) for 7 particles; colors indicate …
[HTML][HTML] Alba shapes the archaeal genome using a delicate balance of bridging and stiffening the DNA
… the DNA stiffness, the measured FD curve will be a linear combination of a FD curve of a
saturated DNA molecule (d saturated (F)) and a FD curve of a bare DNA molecule (d bare (F)). …
saturated DNA molecule (d saturated (F)) and a FD curve of a bare DNA molecule (d bare (F)). …
[HTML][HTML] The fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis
D Vorselen, SM van Dommelen, R Sorkin… - Nature …, 2018 - nature.com
Extracellular vesicles (EVs) are widely studied regarding their role in cell-to-cell communication
and disease, as well as for applications as biomarkers or drug delivery vehicles. EVs …
and disease, as well as for applications as biomarkers or drug delivery vehicles. EVs …
Competition between bending and internal pressure governs the mechanics of fluid nanovesicles
Nanovesicles (∼100 nm) are ubiquitous in cell biology and an important vector for drug
delivery. Mechanical properties of vesicles are known to influence cellular uptake, but the …
delivery. Mechanical properties of vesicles are known to influence cellular uptake, but the …
Phagocytic 'teeth'and myosin-II 'jaw'power target constriction during phagocytosis
Phagocytosis requires rapid actin reorganization and spatially controlled force generation to
ingest targets ranging from pathogens to apoptotic cells. How actomyosin activity directs …
ingest targets ranging from pathogens to apoptotic cells. How actomyosin activity directs …