DNA methylation has been comprehensively profiled in normal and cancer cells, but the
dynamics that form, maintain and reprogram differentially methylated regions remain enigmatic. …

Tumors are composed of phenotypically heterogeneous cancer cells that often resemble
various differentiation states of their lineage of origin. Within this hierarchy, it is thought that an …

… Results in b and d display representative outcomes … c, d Bean plots showing the distribution
of DNA methylation (%mC) of individual CpGs, both genome wide (c) and at CpG islands (d). …

Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can
be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous …

Conventional single cell RNA-seq methods are destructive, such that a given cell cannot
also then be tested for fate and function, without a time machine. Here, we develop a clonal …

Somatic cells can be inefficiently and stochastically reprogrammed into induced pluripotent
stem (iPS) cells by exogenous expression of Oct4 (also called Pou5f1), Sox2, Klf4 and Myc (…

A genome scan meta-a nalysis (GSMA) was carried out on 32 independent genome-wide
linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected with …

Induced pluripotent stem cells (iPSCs) can be derived from somatic cells by ectopic expression
of different transcription factors, classically Oct4 (also known as Pou5f1), Sox2, Klf4 and …

Understanding the principles governing mammalian gene regulation has been hampered by
the difficulty in measuring in vivo binding dynamics of large numbers of transcription factors …

… (d,e) Beads are washed to reduce unspecific interactions (d) and the sample is eluted
from the beads, treated with RNase and proteinase K and is then reverse cross-linked (e). (f) …