… by de Rooij and Grootegoed (1998) and de Rooij et al. … to be virtually the same everywhere
(de Rooij and Lok, 1987), … takes place (de Rooij and Janssen, 1987; de Rooij and Lok, 1987). …

The mammalian seminiferous epithelium consists of a highly complex yet well-organized
cell population, with germ cells in mitosis and meiosis and postmeiotic cells undergoing …

… spermatogonia did not take place (De Rooij et al. 1985). It … all spermatogonia were removed
(De Rooij 1980). Alternatively… drops in early stage VII (Lok & De Rooij 1983b). In the rat the …

The molecular control of self-renewal and differentiation of stem cells has remained enigmatic.
Transgenic loss-of-function and overexpression models now show that the dosage of glial …

Small RNAs associate with Argonaute proteins and serve as sequence-specific guides for
regulation of mRNA stability, productive translation, chromatin organization, and genome …

Adult germline stem cells are capable of self-renewal, tissue regeneration and production of
large numbers of differentiated progeny. We show here that the classical mouse mutant …

… et al., 1984) mice, the Chinese hamster (Lok and de Rooij, 1982; de Rooij et al., 1985) and
the ram (Lok and de Rooij, 1982) substantial quantitative differences were found between the …

Mutations in SOX9 are associated with male-to-female sex reversal in humans 1, 2. To analyze
Sox9 function during sex determination, we ectopically expressed this gene in XX gonads…

In eukaryotes, diploid cells give rise to haploid cells via meiosis, a program of two cell divisions
preceded by one round of DNA replication. Although key molecular components of the …

… Sf1:Cre; Sox9/Sox9 knock-out mice (C,D) showed a varying degree of sex cord formation
(D shows the most severe phenotype observed during this analysis). (E,F) Control ovary and …