Multiple sclerosis (MS) is probably aetiologically heterogeneous. Systematic genetic
epidemiological and molecular genetic studies have provided important insights. Both genetic and …

An accurate diagnosis is an integral component of patient care for children with rare genetic
disease. Recent advances in sequencing, in particular whole‐exome sequencing ( WES ), …

… , DA Dyment, unpublished data), consistent with a threshold/oligo-genic model. Similarly,
age of onset and recurrence risk in other relatives appear to be independent factors influencing …

Size and ascertainment constraints often limit twin studies to concordance comparisons between
identical and fraternal twins. Here we report the final results of a longitudinal, population…

Multiple sclerosis (MS) is a complex trait in which allelic variation in the MHC class II region
exerts the single strongest effect on genetic risk. Epidemiological data in MS provide strong …

Objectives To determine if risk of multiple sclerosis (MS) is associated with month of birth in
countries in the northern hemisphere and if factors related to month of birth interact with …

Background Increased familial risks in multiple sclerosis (MS) range from 300-fold for monozygotic
twins to 20-40-fold for biological first-degree relatives, suggesting a genetic influence. …

Multiple sclerosis is a complex trait in which occurrence rates in offspring are 20–50-fold
greater than in the general population. Parent-of-origin effects have been difficult to screen for, …

Genetic susceptibility to multiple sclerosis is associated with genes of the major histocompatibility
complex (MHC), particularly HLA-DRB1 and HLA-DQB1 (ref. 1 ). Both locus and allelic …

… DA Dyment and KM Boycott are supported by the CIHR Institute of Genetics Clinical
Investigatorship Award. This patient was selected for study by the FORGE Canada Steering …