Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological
age. Here, we use four such age estimators to show that epigenetic aging can be reversed …

… In a parallel study, Lin and Conibear focused on the subset of Palm B-sensitive HDFP targets
to identify the ABHD17 proteins as depalmitoylases for both PSD-95 and N-Ras [36]. Each …

… Lin and Conibear used several biochemical techniques to search for depalmitoylase …
Instead, Lin and Conibear found that an enzyme called ABHD17 removes palmitate from N-Ras. …

… David TS Lin, Elizabeth Conibear; Enzymatic protein depalmitoylation by acyl protein …
Lin, unpublished observations]. This warrants a closer look at the localization and function …

The geroscience hypothesis proposes that therapy to slow or reverse molecular changes
that occur with aging can delay or prevent multiple chronic diseases and extend healthy …

Regulatory T cell (Treg) therapy is a promising approach to improve outcomes in transplantation
and autoimmunity. In conventional T cell therapy, chronic stimulation can result in poor …

Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks …

The development of biological markers of aging has primarily focused on adult samples.
Epigenetic clocks are a promising tool for measuring biological age that show impressive …

Background The capacity of technologies measuring DNA methylation (DNAm) is rapidly
evolving, as are the options for applicable bioinformatics methods. The most commonly used …

Background Higher maternal plasma glucose (PG) concentrations, even below gestational
diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes, with …