User profiles for DE Orange

Didier Orange

IRD
Verified email at ird.fr
Cited by 3904

[HTML][HTML] Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation

…, LB Ivashkiv, VP Bykerk, DE Orange… - Nature …, 2018 - nature.com
d Microscope image screen capture directly from the instrument. Cells and barcoded
microparticles are visualized easily on the screen. e Microscope image of droplets output from the …

[HTML][HTML] Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes

…, J Mears, K Slowikowski, K Weinand, DE Orange… - Nature, 2023 - nature.com
Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation
and destruction 1 . There is currently no cure for rheumatoid arthritis, and the effectiveness of …

Identification of three rheumatoid arthritis disease subtypes by machine learning integration of synovial histologic features and RNA sequencing data

DE Orange, P Agius, EF DiCarlo… - Arthritis & …, 2018 - Wiley Online Library
Objective In this study, we sought to refine histologic scoring of rheumatoid arthritis ( RA )
synovial tissue by training with gene expression data and machine learning. Methods Twenty …

Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis

…, RB Darnell, WH Robinson, DE Orange - Science translational …, 2023 - science.org
Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have
detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal …

[HTML][HTML] RNA identification of PRIME cells predicting rheumatoid arthritis flares

DE Orange, V Yao, K Sawicka, J Fak… - … England Journal of …, 2020 - Mass Medical Soc
Background Rheumatoid arthritis, like many inflammatory diseases, is characterized by
episodes of quiescence and exacerbation (flares). The molecular events leading to flares are …

[BOOK][B] Emotional understanding: Studies in psychoanalytic epistemology

DM Orange - 1995 - books.google.com
Orange illuminates the nature and process of psychoanalytic understanding within the
intimate and healing human context of treatment. Moving away from objectivist empiricism and its …

Runoff and sediment losses from 27 upland catchments in Southeast Asia: Impact of rapid land use changes and conservation practices

…, A De Rouw, JL Janeau, D Orange… - Agriculture, Ecosystems …, 2008 - Elsevier
Rapid changes in upland farming systems in Southeast Asia generated predominantly by
increased population pressure and ‘market forces’ have resulted in widespread land …

Mitochondrial introgression and incomplete lineage sorting through space and time: phylogenetics of crotaphytid lizards

…, MS Koo, DW Hutchison, AK Lappin, DI Orange… - …, 2007 - academic.oup.com
We investigate the roles of mitochondrial introgression and incomplete lineage sorting
during the phylogenetic history of crotaphytid lizards. Our Bayesian phylogenetic estimate for …

Cold-seeps and authigenic carbonate formation in Monterey Bay, California

DS Stakes, D Orange, JB Paduan, KA Salamy… - Marine Geology, 1999 - Elsevier
… as determined by microprobe; D=dolomite; F=feldspar; HMC=high Mg calcite; Q=quartz. …
(d) Note size range of spheroidal pyrite is 5–20 μm and each framboid is composed of …

[PDF][PDF] Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression

…, S Raychauduri, M Bombardieri, C Pitzalis, DE Orange… - Cell reports, 2022 - cell.com
Ectopic lymphoid structures (ELS) can develop in rheumatoid arthritis (RA) synovial tissue,
but the precise pathways of B cell activation and selection are not well understood. Here, we …