[HTML][HTML] Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs

…, SA Semick, RW Bürli, JC Barrow, DJ Hiler… - Nature …, 2020 - nature.com
Human induced pluripotent stem cells (hiPSCs) are a powerful model of neural differentiation
and maturation. We present a hiPSC transcriptomics resource on corticogenesis from 5 …

Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance

…, F Farinelli, Z Ye, Y Wang, DJ Hiler… - Proceedings of the …, 2022 - National Acad Sciences
Neurons derived from human induced pluripotent stem cells (hiPSCs) have been used to
model basic cellular aspects of neuropsychiatric disorders, but the relationship between the …

Reprogramming of mouse retinal neurons and standardized quantification of their differentiation in 3D retinal cultures

DJ Hiler, ME Barabas, LM Griffiths, MA Dyer - Nature protocols, 2016 - nature.com
Postmitotic differentiated neurons are among the most difficult cells to reprogram into
induced pluripotent stem cells (iPSCs) because they have poor viability when cultured as …

Imaging gene expression in live transgenic mice after providing luciferin in drinking water

DJ Hiler, ML Greenwald, ME Geusz - Photochemical & Photobiological …, 2006 - Springer
Mice expressing the firefly luciferase gene luc under the control of various gene promoters
are used to image long-term changes in tumor growth, infection, development, and circadian …

Elevated mPer1 gene expression in tumor stroma imaged through bioluminescence

ME Geusz, KT Blakely, DJ Hiler… - International journal of …, 2010 - Wiley Online Library
The tumor stroma has significant effects on cancer cell growth and metastasis. Interactions
between cancer and stromal cells shape tumor progression through poorly understood …

Circadian mPer1 gene expression in mesencephalic trigeminal nucleus cultures

DJ Hiler, A Bhattacherjee, S Yamazaki, H Tei… - Brain research, 2008 - Elsevier
The circadian timing system includes the major circadian pacemaker in the suprachiasmatic
nucleus (SCN) of the hypothalamus and less well characterized circadian pacemakers in …

Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance

…, SR Sripathy, F Farinelli, Z Ye, Y Wang, DJ Hiler… - BioRxiv, 2021 - biorxiv.org
Neurons derived from human induced pluripotent stem cells (hiPSCs) have been used to
model basic cellular aspects of neuropsychiatric disorders, but the relationship between the …

302. Investigating the Impact of Common Genetic Risk Variants for Schizophrenia on Neuronal Function Elucidates Relationships Between Cellular Phenotypes …

…, Y Wang, D Das, G Shim, DJ Hiler… - Biological …, 2023 - biologicalpsychiatryjournal.com
Background Schizophrenia (SCZ) is a complex, polygenic disorder with marked clinical
heterogeneity and no clear pathological mechanism or cellular pathology. We investigated …

Bioluminescence imaging of transgene expression at the whole-mouse level and in the mesencephalic trigeminal nucleus

DJ Hiler - 2009 - search.proquest.com
Bioluminescence imaging (BLI) of transgenic mice expressing the firefly luciferase gene luc
has been used to monitor continuous changes in gene expression in cultures and in the …

Active control of flow and near-field pressure fluctuations in heated supersonic rectangular twin jets

…, R Leahy, N Webb, A Yarlagadda, N Hiler - Journal of Fluid …, 2024 - cambridge.org
… In this paper, we will use the fully expanded jet equivalent diameter, Dj, rather than the
nozzle exit equivalent diameter, to be consistent in the use of fully expanded parameters. The …