User profiles for Da-Zhi Wang
 | Da-zhi WangProfessor, University of South Florida Verified email at usf.edu Cited by 21960 |
The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
Understanding the molecular mechanisms that regulate cellular proliferation and
differentiation is a central theme of developmental biology. MicroRNAs (miRNAs) are a class of …
differentiation is a central theme of developmental biology. MicroRNAs (miRNAs) are a class of …
[HTML][HTML] Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor
Serum response factor (SRF) regulates transcription of numerous muscle and growth factor-inducible
genes. Because SRF is not muscle specific, it has been postulated to activate …
genes. Because SRF is not muscle specific, it has been postulated to activate …
Myocardin is a master regulator of smooth muscle gene expression
Virtually all smooth muscle genes analyzed to date contain two or more essential binding
sites for serum response factor (SRF) in their control regions. Because SRF is expressed in a …
sites for serum response factor (SRF) in their control regions. Because SRF is expressed in a …
[HTML][HTML] MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
MicroRNAs (miRNAs) are a class of small noncoding RNAs that have gained status as
important regulators of gene expression. Here, we investigated the function and molecular …
important regulators of gene expression. Here, we investigated the function and molecular …
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies
Study of monogenic mitochondrial cardiomyopathies may yield insights into mitochondrial
roles in cardiac development and disease. Here, we combined patient-derived and …
roles in cardiac development and disease. Here, we combined patient-derived and …
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure
Cardiovascular disease is the leading cause of human morbidity and mortality. Dilated
cardiomyopathy (DCM) is the most common form of cardiomyopathy associated with heart failure. …
cardiomyopathy (DCM) is the most common form of cardiomyopathy associated with heart failure. …
Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression
Smooth muscle cells switch between differentiated and proliferative phenotypes in response
to extracellular cues 1 , but the transcriptional mechanisms that confer such phenotypic …
to extracellular cues 1 , but the transcriptional mechanisms that confer such phenotypic …
microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7
Skeletal muscle satellite cells are adult stem cells responsible for postnatal skeletal muscle
growth and regeneration. Paired-box transcription factor Pax7 plays a central role in satellite …
growth and regeneration. Paired-box transcription factor Pax7 plays a central role in satellite …
Potentiation of serum response factor activity by a family of myocardin-related transcription factors
Myocardin is a SAP (SAF-A/B, Acinus, PIAS) domain transcription factor that associates with
serum response factor (SRF) to potently enhance SRF-dependent transcription. Here we …
serum response factor (SRF) to potently enhance SRF-dependent transcription. Here we …
Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy
MicroRNAs (miRNAs) are a recently discovered class of ∼22-nucleotide regulatory RNAs
that post-transcriptionally regulate gene expression. We have recently demonstrated that …
that post-transcriptionally regulate gene expression. We have recently demonstrated that …