[HTML][HTML] A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice
…, C Yau, JGH Low, S Kalimuddin, D Matsuda… - Molecular Therapy, 2021 - cell.com
A self-transcribing and replicating RNA (STARR)-based vaccine (LUNAR-COV19) has been
developed to prevent SARS-CoV-2 infection. The vaccine encodes an alphavirus-based …
developed to prevent SARS-CoV-2 infection. The vaccine encodes an alphavirus-based …
[HTML][HTML] Engineered tRNAs suppress nonsense mutations in cells and in vivo
…, JS Hong, K Tachikawa, P Karmali, D Matsuda… - Nature, 2023 - nature.com
Nonsense mutations are the underlying cause of approximately 11% of all inherited genetic
diseases 1 . Nonsense mutations convert a sense codon that is decoded by tRNA into a …
diseases 1 . Nonsense mutations convert a sense codon that is decoded by tRNA into a …
[PDF][PDF] UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps
Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance mechanism that in
mammals generally occurs upon recognition of a premature termination codon (PTC) during a …
mammals generally occurs upon recognition of a premature termination codon (PTC) during a …
[HTML][HTML] The tRNA-like structure of Turnip yellow mosaic virus RNA is a 3′-translational enhancer
D Matsuda, TW Dreher - Virology, 2004 - Elsevier
Many positive stand RNA viral genomes lack the poly(A) tail that is characteristic of cellular
mRNAs and that promotes translation in cis. The 3′ untranslated regions (UTRs) of such …
mRNAs and that promotes translation in cis. The 3′ untranslated regions (UTRs) of such …
Close spacing of AUG initiation codons confers dicistronic character on a eukaryotic mRNA
D Matsuda, TW Dreher - Rna, 2006 - rnajournal.cshlp.org
TYMV RNA supports the translation of two proteins, p69 and p206, from AUG initiation codons
7 nucleotides apart. We have studied the translation of this overlapping dicistronic mRNA …
7 nucleotides apart. We have studied the translation of this overlapping dicistronic mRNA …
Translation regulation by ribosomes: Increased complexity and expanded scope
VP Mauro, D Matsuda - RNA biology, 2016 - Taylor & Francis
The primary function of ribosomes is to decode mRNAs into polypeptide chains; however,
this description is overly simplistic. Accumulating evidence shows that ribosomes themselves …
this description is overly simplistic. Accumulating evidence shows that ribosomes themselves …
[HTML][HTML] eEF1A binding to aminoacylated viral RNA represses minus strand synthesis by TYMV RNA-dependent RNA polymerase
D Matsuda, S Yoshinari, TW Dreher - Virology, 2004 - Elsevier
The genomic RNA of Turnip yellow mosaic virus (TYMV) has an 82-nucleotide-long tRNA-like
structure at its 3′-end that can be valylated and then form a stable complex with …
structure at its 3′-end that can be valylated and then form a stable complex with …
Base pairing between hepatitis C virus RNA and 18S rRNA is required for IRES-dependent translation initiation in vivo
D Matsuda, VP Mauro - Proceedings of the National …, 2014 - National Acad Sciences
Degeneracy in eukaryotic translation initiation is evident in the initiation strategies of various
viruses. Hepatitis C virus (HCV) provides an exceptional example—translation of the HCV …
viruses. Hepatitis C virus (HCV) provides an exceptional example—translation of the HCV …
[HTML][HTML] Determinants of initiation codon selection during translation in mammalian cells
D Matsuda, VP Mauro - PloS one, 2010 - journals.plos.org
Factors affecting translation of mRNA contribute to the complexity of eukaryotic proteomes. In
some cases, translation of a particular mRNA can generate multiple proteins. However, the …
some cases, translation of a particular mRNA can generate multiple proteins. However, the …
Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA
D Matsuda, N Hosoda, YK Kim… - Nature structural & …, 2007 - nature.com
Nonsense-mediated mRNA decay (NMD) generally eliminates messenger RNAs that
prematurely terminate translation and occurs in all eukaryotes that have been studied, although …
prematurely terminate translation and occurs in all eukaryotes that have been studied, although …