The overwhelming majority of participants in current genetic studies are of European ancestry.
To elucidate disease biology in the East Asian population, we conducted a genome-wide …

Hepatitis B virus (HBV) infection is a major health issue worldwide which may lead to hepatic
dysfunction, liver cirrhosis and hepatocellular carcinoma. To identify host genetic factors …

Lung cancer is the most common cause of death from cancer worldwide, and its incidence
is increasing in East Asian and Western countries. To identify genetic factors that modify the …

Chronic viral hepatitis is the most important risk factor for progression to hepatocellular
carcinoma (HCC). To identify genetic risk factors for progression to HCC in individuals with …

BACKGROUND & AIMS: A common genetic variation at the IL28 locus has been found to
affect the response of peg-interferon and ribavirin combination therapy against chronic …

Over the past several years, the success of genome‐wide association studies ( GWAS ) and
pharmacogenomics has gradually begun to enable personalized medicine in some fields. In …

The non-structural X protein, HBx, of hepatitis B virus (HBV) is assumed to play an important
role in HBV replication. Woodchuck hepatitis virus X protein is indispensable for virus …

Background. Pegylated interferon, ribavirin, and telaprevir triple therapy is a new strategy
expected to eradicate the hepatitis C virus (HCV) even in patients infected with difficult-to-treat …

Background & Aims Circulating tumor DNA (ctDNA) carrying tumor-specific sequence
alterations has been found in the cell-free fraction of blood. Liver cancer tumor specimens are …

Background Treatment for chronic hepatitis B has improved drastically with the use of
nucleot(s)ide analogues (NAs). However, NA therapy typically fails to eliminate Hepatitis B virus (…