The development of technologies for the in vitro amplification of abnormal conformations of
prion protein (PrP Sc ) has generated the potential for sensitive detection of prions. Here we …

The prion-like seeding of misfolded α-synuclein (αSyn) involved in the pathogenesis of
Lewy body diseases (LBD) remains poorly understood at the molecular level. Using the real-time …

Prion diseases are fatal neurodegenerative disorders and no effective treatment has been
established to date. In this study, we evaluated the effect of FK506 (tacrolimus), a macrolide …

We present an extensive study on inhomogeneous chiral condensates in QCD at finite
density in the chiral limit using a generalized Ginzburg-Landau (GL) approach. Performing …

Objectives The tumor microenvironment, including tumor‐infiltrating lymphocytes and
myeloid‐derived cells, is an important factor in the pathogenesis and clinical behavior of malignant …

Prion diseases are characterized by the accumulation of amyloid fibrils. The causative agent
is an infectious amyloid that comprises solely misfolded prion protein (PrP Sc ). Prions can …

Prion diseases are neurodegenerative disorders characterized by the aggregation of abnormally
folded prion protein (PrP Sc ). In this study, we focused on the mechanism of clearance …

The Sokal and Hasford scores were developed in the chemotherapy and interferon era and
are widely used as prognostic indicators in patients with chronic myeloid leukemia ( CML ). …

We have found that visible light irradiation of a reaction mixture of dimethoxy-coordinated
tetraphenylporphyrinatoantimony (V) as a sensitizer, potassium hexachloroplatinate (IV) as an …

Prion diseases are fatal neurodegenerative disorders characterized by the accumulation of
prion protein (PrP C ). To date, there is no effective treatment for the disease. The …