[PDF][PDF] The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance
T Akiyama, Y Shimo, H Yanai, J Qin, D Ohshima… - Immunity, 2008 - cell.com
Medullary thymic epithelial cells (mTECs) establish T cell self-tolerance through the expression
of autoimmune regulator (Aire) and peripheral tissue-specific self-antigens. However, …
of autoimmune regulator (Aire) and peripheral tissue-specific self-antigens. However, …
[HTML][HTML] Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer
T Nishina, Y Deguchi, D Ohshima, W Takeda… - Nature …, 2021 - nature.com
Interleukin (IL)-11 is a member of the IL-6 family of cytokines and is involved in multiple
cellular responses, including tumor development. However, the origin and functions of IL-11-…
cellular responses, including tumor development. However, the origin and functions of IL-11-…
Limitation of immune tolerance–inducing thymic epithelial cell development by Spi-B–mediated negative feedback regulation
…, H Yanai, R Tateishi, Y Shimo, D Ohshima… - Journal of Experimental …, 2014 - rupress.org
Medullary thymic epithelial cells (mTECs) expressing the autoimmune regulator AIRE and
various tissue-specific antigens (TSAs) are critical for preventing the onset of autoimmunity …
various tissue-specific antigens (TSAs) are critical for preventing the onset of autoimmunity …
Human SLC15A4 is crucial for TLR-mediated type I interferon production and mitochondrial integrity
T Kobayashi, D Nguyen-Tien, D Ohshima… - International …, 2021 - academic.oup.com
Solute carrier family 15 member 4 (SLC15A4) is an endolysosome-resident amino acid
transporter that regulates innate immune responses, and is genetically associated with …
transporter that regulates innate immune responses, and is genetically associated with …
Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells
…, K Furuyama-Tanaka, D Ohshima… - International …, 2017 - academic.oup.com
Mast cells possess specialized lysosomes, so-called secretory granules, which play a key
role not only in allergic responses but also in various immune disorders. The molecular …
role not only in allergic responses but also in various immune disorders. The molecular …
[HTML][HTML] Pathogenic mechanism of dry eye–induced chronic ocular pain and a mechanism-based therapeutic approach
…, Y Mikami, M Ito, T Tomida, D Ohshima… - … & Visual Science, 2022 - iovs.arvojournals.org
Purpose: Dry eye–induced chronic ocular pain is also called ocular neuropathic pain. However,
details of the pathogenic mechanism remain unknown. The purpose of this study was to …
details of the pathogenic mechanism remain unknown. The purpose of this study was to …
TRAF6 directs commitment to regulatory T cells in thymocytes
Y Shimo, H Yanai, D Ohshima, J Qin, H Motegi… - Genes to …, 2011 - Wiley Online Library
Regulatory T cells (Tregs), a subset of CD4 + helper T cells, are crucial for immunological
self‐tolerance. Defect in development or function of Tregs results in autoimmune disease in …
self‐tolerance. Defect in development or function of Tregs results in autoimmune disease in …
[HTML][HTML] Spatio-temporal dynamics and mechanisms of stress granule assembly
D Ohshima, K Arimoto-Matsuzaki… - PLoS computational …, 2015 - journals.plos.org
Stress granules (SGs) are non-membranous cytoplasmic aggregates of mRNAs and related
proteins, assembled in response to environmental stresses such as heat shock, hypoxia, …
proteins, assembled in response to environmental stresses such as heat shock, hypoxia, …
Lack of an inducible effect of dietary soy isoflavones on the mRNA abundance of hepatic cytochrome P-450 isozymes in rats
…, Y Ohtsu, M Watakabe, D Ohshima… - Bioscience …, 2004 - jstage.jst.go.jp
Modulation of the activity and content of cytochrome P-450 (CYP) in hepatic microsomes may
be important to human health since these enzymes activate and inactivate a wide range of …
be important to human health since these enzymes activate and inactivate a wide range of …
[HTML][HTML] Roles of spatial parameters on the oscillation of nuclear NF-κB: computer simulations of a 3D spherical cell
D Ohshima, J Inoue, K Ichikawa - 2012 - journals.plos.org
Transcription factor NF-κB resides in the cytoplasm and translocates to the nucleus by
application of extracellular stimuli. It is known that the nuclear NF-κB oscillates and different …
application of extracellular stimuli. It is known that the nuclear NF-κB oscillates and different …