Base editors are fusions of a deaminase and CRISPR-Cas ribonucleoprotein that allow
programmable installment of transition mutations without double-strand DNA break intermediates…

Resolving fundamental molecular and functional processes underlying human synaptic
development is crucial for understanding normal brain function as well as dysfunction in disease…

Background There is much interest in confirming whether the efficacy of abiraterone acetate
(AA) demonstrated within the trial setting is reproducible in routine clinical practice. We …

CRISPR-Cas9-mediated gene interference (CRISPRi) and activation (CRISPRa) approaches
hold promise for functional gene studies and genome-wide screens in human pluripotent …

Objectives Chemotherapy-induced nausea and vomiting (CINV) are distressing symptoms.
This randomized study evaluated the antiemetic efficacies of standard antiemetic regimen …

… WKJ Lam reports other from Grail, Inc. outside the submitted work; in addition, WKJ Lam has
multiple patent applications on molecular diagnostics using cell-free nucleic acids pending. …

Purpose.: We investigated the progressive nature of neurodegenerative structural changes
following injury to retinal ganglion cell (RGC) axons using quantifiable and noninvasive in …

Down syndrome (DS), driven by an extra copy of chromosome 21 (HSA21), and fragile X
syndrome (FXS), driven by loss of the RNA-binding protein FMRP, are two common genetic …

Simple Summary With the recognition that ethnicity may influence prognosis and outcomes,
there are ongoing controversies over how best to treat patients with prostate cancer. This …

Scaling of CRISPR-Cas9 technology in human pluripotent stem cells (hPSCs) represents an
important step for modeling complex disease and developing drug screens in human cells. …