User profiles for Dalam Ly
 | Dalam LyUniversity Health Network Verified email at uhnresearch.ca Cited by 1661 |
Tumor-infiltrating B cells: their role and application in anti-tumor immunity in lung cancer
S Wang, W Liu, D Ly, H Xu, L Qu, L Zhang - Cellular & molecular …, 2019 - nature.com
Evidence indicates that lung cancer development is a complex process that involves interactions
between tumor cells, stromal fibroblasts, and immune cells. Tumor-infiltrating immune …
between tumor cells, stromal fibroblasts, and immune cells. Tumor-infiltrating immune …
CD1a, CD1b, and CD1c in immunity against mycobacteria
I Van Rhijn, D Ly, DB Moody - The new paradigm of immunity to …, 2013 - Springer
The CD1 system is composed of five types of human CD1 proteins, CD1a, CD1b, CD1c,
CD1d, and CD1e, and their mammalian orthologs. Each type of CD1 protein has a distinct …
CD1d, and CD1e, and their mammalian orthologs. Each type of CD1 protein has a distinct …
Bee venom processes human skin lipids for presentation by CD1a
Venoms frequently co-opt host immune responses, so study of their mode of action can
provide insight into novel inflammatory pathways. Using bee and wasp venom responses as a …
provide insight into novel inflammatory pathways. Using bee and wasp venom responses as a …
CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens
CD1c is expressed with high density on human dendritic cells (DCs) and B cells, yet its antigen
presentation functions are the least well understood among CD1 family members. Using …
presentation functions are the least well understood among CD1 family members. Using …
The CD1 size problem: lipid antigens, ligands, and scaffolds
D Ly, DB Moody - Cellular and molecular life sciences, 2014 - Springer
Whereas research on CD1d has emphasized a few glycosyl ceramides, the broader family
of four human CD1 antigen-presenting molecules binds hundreds of distinct self-lipids. …
of four human CD1 antigen-presenting molecules binds hundreds of distinct self-lipids. …
Blockade of tumor necrosis factor-related apoptosis-inducing ligand exacerbates type 1 diabetes in NOD mice
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is expressed in
different tissues and cells, including pancreas and lymphocytes, and can induce apoptosis in …
different tissues and cells, including pancreas and lymphocytes, and can induce apoptosis in …
Molecular analysis of lipid-reactive Vδ1 γδ T cells identified by CD1c tetramers
CD1c is abundantly expressed on human dendritic cells (DC) and B cells, where it binds
and displays lipid Ags to T cells. In this study, we report that CD1c tetramers carrying …
and displays lipid Ags to T cells. In this study, we report that CD1c tetramers carrying …
Allogeneic human double negative T cells as a novel immunotherapy for acute myeloid leukemia and its underlying mechanisms
Purpose: To explore the potential of ex vivo expanded healthy donor–derived allogeneic
CD4 and CD8 double-negative cells (DNT) as a novel cellular immunotherapy for leukemia …
CD4 and CD8 double-negative cells (DNT) as a novel cellular immunotherapy for leukemia …
Protection from type 1 diabetes by invariant NK T cells requires the activity of CD4+ CD25+ regulatory T cells
Invariant NK T (iNKT) cells regulate immune responses, express NK cell markers and an
invariant TCR, and recognize lipid Ags in a CD1d-restricted manner. Previously, we reported …
invariant TCR, and recognize lipid Ags in a CD1d-restricted manner. Previously, we reported …
Interleukin-4 but not interleukin-10 protects against spontaneous and recurrent type 1 diabetes by activated CD1d-restricted invariant natural killer T-cells
In nonobese diabetic (NOD) mice, a deficiency in the number and function of invariant natural
killer T-cells (iNKT cells) contributes to the onset of type 1 diabetes. The activation of CD1d-…
killer T-cells (iNKT cells) contributes to the onset of type 1 diabetes. The activation of CD1d-…