DNA methylation-based classification of central nervous system tumours
…, K Huang, KW Pajtler, L Schweizer, D Stichel… - Nature, 2018 - nature.com
Accurate pathological diagnosis is crucial for optimal management of patients with cancer.
For the approximately 100 known tumour types of the central nervous system, standardization …
For the approximately 100 known tumour types of the central nervous system, standardization …
DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis
Background The WHO classification of brain tumours describes 15 subtypes of meningioma.
Nine of these subtypes are allotted to WHO grade I, and three each to grade II and grade III. …
Nine of these subtypes are allotted to WHO grade I, and three each to grade II and grade III. …
[HTML][HTML] Sarcoma classification by DNA methylation profiling
C Koelsche, D Schrimpf, D Stichel, M Sill… - Nature …, 2021 - nature.com
Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and
children. They represent a morphologically heterogeneous class of tumours and some entities …
children. They represent a morphologically heterogeneous class of tumours and some entities …
[HTML][HTML] Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience
Recently, we described a machine learning approach for classification of central nervous
system tumors based on the analysis of genome-wide DNA methylation patterns [ 6 ]. Here, we …
system tumors based on the analysis of genome-wide DNA methylation patterns [ 6 ]. Here, we …
[HTML][HTML] Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology
The large diversity of central nervous system (CNS) tumor types in children and adolescents
results in disparate patient outcomes and renders accurate diagnosis challenging. In this …
results in disparate patient outcomes and renders accurate diagnosis challenging. In this …
Novel, improved grading system (s) for IDH-mutant astrocytic gliomas
M Shirahata, T Ono, D Stichel, D Schrimpf… - Acta …, 2018 - Springer
… Automated assessment of copy-number changes was performed using a proprietary algorithm
(Stichel D and colleagues, unpublished). This allowed determining CNV load (CNV-L) for …
(Stichel D and colleagues, unpublished). This allowed determining CNV load (CNV-L) for …
[HTML][HTML] Integrated molecular-morphologic meningioma classification: a multicenter retrospective analysis, retrospectively and prospectively validated
SLN Maas, D Stichel, T Hielscher… - Journal of clinical …, 2021 - ncbi.nlm.nih.gov
PURPOSE Meningiomas are the most frequent primary intracranial tumors. Patient outcome
varies widely from benign to highly aggressive, ultimately fatal courses. Reliable …
varies widely from benign to highly aggressive, ultimately fatal courses. Reliable …
Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the …
D Stichel, A Ebrahimi, D Reuss, D Schrimpf, T Ono… - Acta …, 2018 - Springer
EGFR amplification (EGFRamp), the combination of gain of chromosome 7 and loss of
chromosome 10 (7+/10−), and TERT promoter mutation (pTERTmut) are alterations frequently …
chromosome 10 (7+/10−), and TERT promoter mutation (pTERTmut) are alterations frequently …
Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations
A Reinhardt, D Stichel, D Schrimpf, F Sahm… - Acta …, 2018 - Springer
Tumors with histological features of pilocytic astrocytoma (PA), but with increased mitotic
activity and additional high-grade features (particularly microvascular proliferation and …
activity and additional high-grade features (particularly microvascular proliferation and …
[PDF][PDF] Evolutionary trajectories of IDHWT glioblastomas reveal a common path of early tumorigenesis instigated years ahead of initial diagnosis
We studied how intratumoral genetic heterogeneity shapes tumor growth and therapy response
for isocitrate dehydrogenase (IDH)-wild-type glioblastoma, a rapidly regrowing tumor. …
for isocitrate dehydrogenase (IDH)-wild-type glioblastoma, a rapidly regrowing tumor. …