In female meiosis, chromosome missegregations lead to the generation of aneuploid oocytes
and can cause the development of trisomies or infertility. Because mammalian female …

Mammalian female meiosis is error prone, with rates of meiotic chromosome missegregations
strongly increasing towards the end of the reproductive lifespan. A strong reduction of …

A key feature of meiosis is the step-wise removal of cohesin, the protein complex holding
sister chromatids together, first from arms in meiosis I and then from the centromere region in …

Cell division with partitioning of the genetic material should take place only when paired
chromosomes named bivalents (meiosis I) or sister chromatids (mitosis and meiosis II) are …

In the presented work we aimed at improving confocal imaging to obtain highest possible
resolution in thick biological samples, such as the mouse oocyte. We therefore developed an …

To ensure successful offspring ploidy, vertebrate oocytes must halt the cell cycle in meiosis
II until sperm entry. Emi2 is essential to keep oocytes arrested until fertilization. However, …

Haploid gametes are generated through two consecutive meiotic divisions, with the
segregation of chromosome pairs in meiosis I and sister chromatids in meiosis II. Separase-…

To generate haploid gametes, cohesin is removed in a stepwise manner from chromosome
arms in meiosis I and the centromere region in meiosis II to segregate chromosomes and …

Partitioning of the genome in meiosis occurs through two highly specialized cell divisions,
named meiosis I and meiosis II. Step‐wise cohesin removal is required for chromosome …

In meiosis, two specialized cell divisions allow the separation of paired chromosomes first,
then of sister chromatids. Separase removes the cohesin complex holding sister chromatids …