The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) disease (COVID-19)
pandemic has caused millions of deaths worldwide. Genome-wide association studies …

Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete
description of specific immune biomarkers. We present here a comprehensive multi-omic …

In higher eukaryotes, many genes are regulated by enhancers that are 10 4 –10 6 base
pairs (bp) away from the promoter. Enhancers contain transcription-factor-binding sites (which …

The genome is organized via CTCF–cohesin-binding sites, which partition chromosomes into
1–5 megabase (Mb) topologically associated domains (TADs), and further into smaller sub-…

Predicting the impact of noncoding genetic variation requires interpreting it in the context of
three-dimensional genome architecture. We have developed deepC, a transfer-learning-…

The promoters of mammalian genes are commonly regulated by multiple distal enhancers,
which physically interact within discrete chromatin domains. How such domains form and …

Enhancer elements are a key regulatory feature of many important genes. Several general
features including the presence of specific histone modifications are used to demarcate …

Dynamic cellular processes such as differentiation are driven by changes in the abundances
of transcription factors (TFs). However, despite years of studies, our knowledge about the …

β-Thalassemia is one of the most common inherited anemias, with no effective cure for most
patients. The pathophysiology reflects an imbalance between α- and β-globin chains with …

Micro Capture-C (MCC) is a chromatin conformation capture (3C) method for visualizing
reproducible three-dimensional contacts of specified regions of the genome at base pair …