Although many proteins, receptors, and viruses are transported rearward along filopodia by
retrograde actin flow [1–3], it is less clear how molecules move forward in filopodia. Myosin-…

Renal cystic diseases are a leading cause of renal failure. Mutations associated with renal
cystic diseases reside in genes encoding proteins that localize to primary cilia. These …

Class V myosins are actin-based motor proteins that have critical functions in organelle
trafficking. Of the three class V myosins expressed in mammals, relatively little is known about …

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is caused by mutation of PKD1 or
PKD2, which encode polycystin 1 and 2, respectively. The polycystins localize to primary …

Primary cilia are sensory organelles built and maintained by intraflagellar transport (IFT)
multiprotein complexes. Deletion of several IFT-B genes attenuates polycystic kidney disease (…

Myosin-X (Myo10) is an unconventional myosin that localizes to the tips of filopodia and has
critical functions in filopodia. Although Myo10 has been studied primarily in nonpolarized, …

We investigated the role of the actin-based myosin motor, myosin 5c (Myo5c) in vesicle
transport in exocrine secretion. Lacrimal gland acinar cells (LGAC) are the major source for the …

Primary cilia extend from the plasma membrane of most vertebrate cells and mediate signaling
pathways. Ciliary dysfunction underlies ciliopathies, which are genetic syndromes that …

Primary cilia are singular, sensory organelles that extend from the plasma membrane of
most quiescent mammalian cells. These slender, microtubule-based organelles receive and …

The therapeutic usefulness of anticancer agents relies on their ability to exert maximal
toxicity to cancer cells and minimal toxicity to normal cells. The difference between these two …