User profiles for Dan Donnelly

Daniel P. Donnelly

Alnylam
Verified email at alnylam.com
Cited by 410

The structure and function of the glucagon‐like peptide‐1 receptor and its ligands

D Donnelly - British journal of pharmacology, 2012 - Wiley Online Library
Glucagon‐like peptide‐1(7‐36)amide (GLP‐1) is a 30‐residue peptide hormone released
from intestinal L cells following nutrient consumption. It potentiates the glucose‐induced …

Environment‐specific amino acid substitution tables: tertiary templates and prediction of protein folds

J Overington, D Donnelly, MS Johnson, A Šali… - Protein …, 1992 - Wiley Online Library
The local environment of an amino acid in a folded protein determines the acceptability of
mutations at that position. In order to characterize and quantify these structural constraints, we …

Glucagon-like peptide-1 and its class BG protein–coupled receptors: a long march to therapeutic successes

C De Graaf, D Donnelly, D Wootten, J Lau… - Pharmacological …, 2016 - ASPET
The glucagon-like peptide (GLP)-1 receptor (GLP-1R) is a class BG protein–coupled receptor
(GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three major …

[HTML][HTML] Best practices and benchmarks for intact protein analysis for top-down mass spectrometry

DP Donnelly, CM Rawlins, CJ DeHart, L Fornelli… - Nature …, 2019 - nature.com
One gene can give rise to many functionally distinct proteoforms, each of which has a
characteristic molecular mass. Top-down mass spectrometry enables the analysis of intact proteins …

Control of ferulic acid and 4‐vinyl guaiacol in brewing

I McMurrough, D Madigan, D Donnelly… - Journal of the …, 1996 - Wiley Online Library
Phenolic acids in beer are important because they can be decarboxylated to phenols, which
usually impart off‐flavours. An improved high performance liquid chromatographic system …

[HTML][HTML] The isolated N-terminal domain of the glucagon-like peptide-1 (GLP-1) receptor binds exendin peptides with much higher affinity than GLP-1

…, A Kuntzsch, R Rudolph, D Donnelly - Journal of Biological …, 2003 - ASBMB
Two fragments of the receptor for glucagon-like peptide-1 (GLP-1), each containing the N-terminal
domain, were expressed and characterized in either bacterial or mammalian cells. …

Cognitive and emotional changes in written essays and therapy interviews

DA Donnelly, EJ Murray - Journal of Social and Clinical psychology, 1991 - Guilford Press
The purpose of this study was to examine the cathartic and therapeutic effects of written
essays and therapy interviews about traumatic events over four successive days as compared …

A model for receptor–peptide binding at the glucagon‐like peptide‐1 (GLP‐1) receptor through the analysis of truncated ligands and receptors

S Al‐Sabah, D Donnelly - British journal of pharmacology, 2003 - Wiley Online Library
The receptor for glucagon‐like peptide‐1 (GLP‐1) can be activated by both its physiological
hormone and a peptide discovered in the venom of the Gila Monster, exendin‐4, which …

Aneuploidy and copy number breakpoints in the genome of lager yeasts mapped by microarray hybridisation

U Bond, C Neal, D Donnelly, TC James - Current genetics, 2004 - Springer
Competitive comparative genome hybridisation (CCGH) to Saccharomyces cerevisiae DNA
microarrays and quantitative real-time polymerase chain reaction (qRT-PCR) assays are …

Modeling α‐helical transmembrane domains: The calculation and use of substitution tables for lipid‐facing residues

TL Blundell, D Donnelly, JP Overington… - Protein …, 1993 - Wiley Online Library
Amino acid substitution tables are calculated for residues in membrane proteins where the
side chain is accessible to the lipid. The analysis is based upon the knowledge of the three‐…