Plasmacytoid dendritic cells (PDCs) represent a unique immune cell type specialized in type
I interferon (IFN) secretion in response to viral nucleic acids. The molecular control of PDC …

Identification of genes associated with pain insensitivity syndromes can increase the understanding
of the pathways involved in pain and contribute to the understanding of how sensory …

Macrophages are multifunctional immune cells that may either drive or modulate disease
pathogenesis depending on their activation phenotype. Autoimmune type 1 diabetes (T1D) is a …

Cellular telomere length is linked to replicative life span. Telomere repeats are lost in peripheral
blood cells in vivo by age, and women show less telomere attrition than men. Previous …

A convenient technology to quantify three-dimensional (3D) morphological features would
have widespread applications in biomedical research. Based on combined improvements in …

Background and Purpose— Impaired fibrinolytic function secondary to elevated plasminogen
activator inhibitor-1 (PAI-1) levels has been implicated in ischemic stroke. PAI-1 levels are …

We provide the first comprehensive analysis of the extracellular matrix (ECM) composition
of peri-islet capsules, composed of the peri-islet basement membrane (BM) and subjacent …

Mature microRNAs (miRNAs), derived through cleavage of pre-miRNAs by the Dicer1 enzyme,
regulate protein expression in many cell-types including cells in the pancreatic islets of …

… The particular interest of this approach is that components of the actual repertoires of normal
immune systems can be produced in large amounts, compared from donor to donor, (to …

Little is known about target organ-infiltrating NK cells in type 1 diabetes and other autoimmune
diseases. In this study, we identified NK cells with a unique phenotype in the pancreas of …