Growing evidence supports the antagonistic pleiotropy theory of mammalian aging.
Accordingly, changes in gene expression following the pluripotency transition, and subsequent …

Here we present the application of deep neural network (DNN) ensembles trained on
transcriptomic data to identify the novel markers associated with the mammalian embryonic-fetal …

Multicellular life evolved from simple unicellular organisms that could replicate indefinitely,
being essentially ageless. At this point, life split into two fundamentally different cell types: the …

Supercentenarians (≥110-year-old, SC) are a uniquely informative population not only
because they surpass centenarians in age, but because they appear to age more slowly with …

Human pluripotent stem cells (hPSCs) can be used as a renewable source of endothelial
cells for treating cardiovascular disease and other ischemic conditions. Here, we present the …

Background The role of brown fat in non-shivering thermogenesis and the discovery of
brown fat depots in adult humans has made it the subject of intense research interest. A …

The embedding of small peptide ligands within large inactive pre-pro-precursor proteins
encoded by orphan open reading frames (ORFs) makes them difficult to identify and study. To …

Stroke is the number one cause of morbidity in the United States and number two cause of
death worldwide. There is a critical unmet medical need for more effective treatments of …

The cadherin family of cell surface glycoproteins plays a fundamental role in cell-cell recognition,
thereby participating in diverse biological process such as embryonic morphogenesis …

Multicellular life evolved from simple unicellular organisms that could replicate indefinitely,
being essentially ageless. At this point, life split into two fundamentally different cell types: the …