[HTML][HTML] Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways
The clinical, radiographic, and molecular analyses included in this study demonstrate the
efficacy of ONC201 in H3K27M-mutant DMG and support ONC201 as the first monotherapy to …
efficacy of ONC201 in H3K27M-mutant DMG and support ONC201 as the first monotherapy to …
[PDF][PDF] ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization
ATRX, a chromatin remodeler protein, is recurrently mutated in H3F3A-mutant pediatric
glioblastoma (GBM) and isocitrate dehydrogenase (IDH)-mutant grade 2/3 adult glioma. …
glioblastoma (GBM) and isocitrate dehydrogenase (IDH)-mutant grade 2/3 adult glioma. …
Mitotic chromosome alignment ensures mitotic fidelity by promoting interchromosomal compaction during anaphase
…, W Martin, C Byers, A Czechanski, D Messinger… - Journal of Cell …, 2019 - rupress.org
Chromosome alignment at the equator of the mitotic spindle is a highly conserved step
during cell division; however, its importance to genomic stability and cellular fitness is not …
during cell division; however, its importance to genomic stability and cellular fitness is not …
A road map for the treatment of pediatric diffuse midline glioma
Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much
promise. We present a consensus roadmap and identify three major barriers: (1) refinement of …
promise. We present a consensus roadmap and identify three major barriers: (1) refinement of …
[HTML][HTML] Receptor tyrosine kinase (RTK) targeting in pediatric high-grade glioma and diffuse midline glioma: Pre-clinical models and precision medicine
K Schwark, D Messinger, JR Cummings… - Frontiers in …, 2022 - frontiersin.org
Pediatric high-grade glioma (pHGG), including both diffuse midline glioma (DMG) and non-midline
tumors, continues to be one of the deadliest oncologic diagnoses (both henceforth …
tumors, continues to be one of the deadliest oncologic diagnoses (both henceforth …
Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma
D Messinger, MK Harris, JR Cummings… - Neuro …, 2023 - academic.oup.com
Background Diffuse midline gliomas (DMG) are highly invasive brain tumors with rare survival
beyond two years past diagnosis and limited understanding of the mechanism behind …
beyond two years past diagnosis and limited understanding of the mechanism behind …
Liquid biopsy in h3k27m diffuse midline glioma
…, R Doherty, A Gera, B Lau, D Messinger… - Neuro …, 2023 - academic.oup.com
Diffuse midline glioma (DMG) with H3K27M mutation is an aggressive and difficult to treat
pediatric brain tumor. Recurrent gain of function mutations in H3.3 (H3.3A) and H3.1 (H3C2) at …
pediatric brain tumor. Recurrent gain of function mutations in H3.3 (H3.3A) and H3.1 (H3C2) at …
Mitotic chromosome alignment is required for proper nuclear envelope reassembly
…, W Martin, C Byers, A Czechanski, D Messinger… - bioRxiv, 2018 - biorxiv.org
Chromosome alignment at the equator of the mitotic spindle is a highly conserved step
during cell division, however, its importance to genomic stability and cellular fitness are not …
during cell division, however, its importance to genomic stability and cellular fitness are not …
TMET-02. CLINICAL EFFICACY OF ONC201 IN H3K27M-MUTANT DIFFUSE MIDLINE GLIOMAS IS DRIVEN BY DISRUPTION OF INTEGRATED METABOLIC AND …
…, S Mottl, R Cartaxo, V John, D Messinger… - Neuro …, 2023 - academic.oup.com
H3K27M-mutant diffuse midline glioma (DMG) patients have no proven effective therapies
beyond radiation. ONC201, a mitochondrial protease ClpP agonist, has recently …
beyond radiation. ONC201, a mitochondrial protease ClpP agonist, has recently …
Therapeutic targeting of prenatal pontine ID1 signaling in DMG
D Messinger, G Gibson, MK Harris… - 2023 - scholarlyexchange.childrensmercy …
Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive brain tumor with rare survival
beyond two years. This poor prognosis is largely due to the tumor's highly infiltrative and …
beyond two years. This poor prognosis is largely due to the tumor's highly infiltrative and …