Humoral immune responses are tailored to the invading pathogen through regulation of key
transcription factors and their networks. This is critical to establishing effective antibody-…

There has been an extensive body of research focusing on the epidemiology of thrombosis
in adult cancer populations; however, there is significantly less knowledge about thrombosis …

T cells play a critical role in the control of cancer. The development of immune checkpoint
blockers (ICB) aimed at enhancing antitumor T-cell responses has revolutionized cancer …

Naive CD8 + T cell activation results in an autonomous program of cellular proliferation and
differentiation. However, the mechanisms that underpin this process are unclear. Here, we …

TIGIT is an inhibitory receptor on immune cells that outcompetes an activating receptor,
CD226, for shared ligands. Tumor-infiltrating lymphocytes express TIGIT and CD226 on …

The complexity of managing children with chronic disease has led to an increase in the use
of long-term warfarin therapy. Time in therapeutic range (TTR) is the preferred method for …

INTRODUCTION: Extracellular adenosine triphosphate (ATP) is efficiently hydrolyzed to
adenosine by ecto-nucleotidases CD39 and CD73, which converts adenosine-monophosphate (…

Introduction: Adenosine, generated through the hydrolysis of extracellular adenosine
monophosphate (AMP) by the ecto-nucleotidase CD73, is an important mechanism for …

Background TIGIT (T-cell immunoreceptor with Ig and ITIM domains) is an inhibitory receptor
expressed on natural killer (NK) cells, CD8 + T cells, CD4 + T cells and regulatory T cells (T …

❖ CD39 is expressed at both the mRNA and protein level, on both primary and in vitro-derived
myeloid cell populations. ❖ Nanostring profiling confirms CD39 expression and the …