User profiles for Danai Chasioti
 | Danai Chasioti, Ph.DBiogen Verified email at iu.edu Cited by 94 |
Progress in polygenic composite scores in Alzheimer's and other complex diseases
Advances in high-throughput genotyping and next-generation sequencing (NGS) coupled
with larger sample sizes brings the realization of precision medicine closer than ever. …
with larger sample sizes brings the realization of precision medicine closer than ever. …
Mining directional drug interaction effects on myopathy using the FAERS database
Mining high-order drug-drug interaction (DDI) induced adverse drug effects from electronic
health record databases is an emerging area, and very few studies have explored the …
health record databases is an emerging area, and very few studies have explored the …
[HTML][HTML] Integrative analysis of eQTL and GWAS summary statistics reveals transcriptomic alteration in Alzheimer brains
Background Large-scale genome-wide association studies have successfully identified many
genetic variants significantly associated with Alzheimer’s disease (AD), such as rs429358, …
genetic variants significantly associated with Alzheimer’s disease (AD), such as rs429358, …
Transcriptome-guided imaging genetic analysis via a novel sparse CCA algorithm
Imaging genetics is an emerging field that studies the influence of genetic variation on brain
structure and function. The major task is to examine the association between genetic …
structure and function. The major task is to examine the association between genetic …
A/T/N polygenic risk score for cognitive decline in old age
INTRODUCTION We developed a novel polygenic risk score (PRS) based on the A/T/N (amyloid
plaques (A), phosphorylated tau tangles (T), and neurodegeneration (N)) framework …
plaques (A), phosphorylated tau tangles (T), and neurodegeneration (N)) framework …
[BOOK][B] Biomarker-And Pathway-Informed Polygenic Risk Scores for Alzheimer's Disease and Related Disorders
D Chasioti - 2022 - search.proquest.com
Determining an individual’s genetic susceptibility in complex diseases like Alzheimer’s disease
(AD) is challenging as multiple variants each contribute a small portion of the overall risk. …
(AD) is challenging as multiple variants each contribute a small portion of the overall risk. …
Endophenotype-based polygenic risk scores: Prediction of biomarker and clinical progression and dementia
… Danai Chasioti and Dr. Jingwen Yan conceived of the presented … Danai Chasioti and Dr.
Jingwen Yan developed the … Danai Chasioti performed the computations. Dr. Tanner Jacobson …
Jingwen Yan developed the … Danai Chasioti performed the computations. Dr. Tanner Jacobson …
Endophenotype driven polygenic risk scores for Alzheimer's disease: Genetics/endophenotypes
D Chasioti, TY Jacobson, K Nho… - Alzheimer's & …, 2020 - Wiley Online Library
Background Precision medicine is designed to resolve heterogeneity in complex diseases
such as Alzheimer’s (AD) to deliver timely and tailored treatment. Using ADNI data, we …
such as Alzheimer’s (AD) to deliver timely and tailored treatment. Using ADNI data, we …
Biomarker‐based polygenic risk scores for profiling genetic susceptibility in Alzheimer's disease
D Chasioti, TY Jacobson, K Nho… - Alzheimer's & …, 2021 - Wiley Online Library
Background Precision medicine is designed to resolve heterogeneity in complex diseases
such as Alzheimer’s (AD) to deliver timely and tailored treatment. Using ADNI data, we …
such as Alzheimer’s (AD) to deliver timely and tailored treatment. Using ADNI data, we …
A longitudinal analysis for the identification of the factors that affect the case mix index of hospitals in the US
D Chasioti - 2017 - scholarworks.iupui.edu
The present thesis is an analysis of longitudinal data collected through the years 2011-2013,
from a complex of four hospitals located in Indiana, USA. The aim of the analysis was the …
from a complex of four hospitals located in Indiana, USA. The aim of the analysis was the …