The rapidly expanding field of big data analytics has started to play a pivotal role in the
evolution of healthcare practices and research. It has provided tools to accumulate, manage, …

Predicting behavior of large-scale biochemical networks represents one of the greatest
challenges of bioinformatics and computational biology. Computational tools for predicting fluxes …

A computational model for the mitochondrial respiratory chain that appropriately balances
mass, charge, and free energy transduction is introduced and analyzed based on a previously …

1. Concepts from physical chemistry 2. Conventions and calculations for biochemical
systems 3. Chemical kinetics and transport processes

The principles of thermodynamics apply to both equilibrium and nonequilibrium biochemical
systems. The mathematical machinery of the classic thermodynamics, however, mainly …

A computational model of mitochondrial metabolism and electrophysiology is introduced
and applied to analysis of data from isolated cardiac mitochondria and data on phosphate …

The constraint-based approach to analysis of biochemical systems has emerged as a useful
tool for rational metabolic engineering. Flux balance analysis (FBA) is based on the …

As an alternative to kinetic models for the analysis of genome-scale networks, data-driven
constraints-based models have emerged. Constraints-based modeling is centered on the …

Chemical reaction systems operating in nonequilibrium open-system states arise in a great
number of contexts, including the study of living organisms, in which chemical reactions, in …

Reproducibility of experiments is a basic requirement for science. Minimum Information (MI)
guidelines have proved a helpful means of enabling reuse of existing work in modern …