Cysteine is the most intrinsically nucleophilic amino acid in proteins, where its reactivity is
tuned to perform diverse biochemical functions. The absence of a consensus sequence that …

Pyroptosis is a lytic form of programmed cell death mediated by the inflammatory caspase-1,
-4, and -5. We recently discovered that small-molecule inhibitors of the serine peptidases …

Serine hydrolases (SHs) are one of the largest and most diverse enzyme classes in mammals.
They play fundamental roles in virtually all physiological processes and are targeted by …

Serine hydrolases perform crucial roles in many biological processes, and several of these
enzymes are targets of approved drugs for indications such as type 2 diabetes, Alzheimer's …

Small-molecule inhibitors of the serine dipeptidases DPP8 and DPP9 (DPP8/9) induce a lytic
form of cell death called pyroptosis in mouse and human monocytes and macrophages 1 , …

Serine hydrolases are a diverse enzyme class representing ∼1% of all human proteins. The
biological functions of most serine hydrolases remain poorly characterized owing to a lack …

Intracellular pathogens and danger signals trigger the formation of inflammasomes, which
activate inflammatory caspases and induce pyroptosis. The anthrax lethal factor …

High-throughput screening to discover small-molecule modulators of enzymes typically
relies on highly tailored substrate assays, which are not available for poorly characterized …

Val-boroPro (Talabostat, PT-100), a nonselective inhibitor of post-proline cleaving serine
proteases, stimulates mammalian immune systems through an unknown mechanism of action. …

Inflammasomes are multiprotein complexes that activate inflammatory cytokines and induce
pyroptosis in response to intracellular danger‐associated signals. NLRP1 and CARD8 are …