Actin filament assembly at the cell surface of the pathogenic bacterium Listeria monocytogenes
requires the bacterial ActA surface protein and the host cell Arp2/3 complex. Purified Arp2…

Listeria monocytogenes was used as a model intracellular parasite to study stages in the
entry, growth, movement, and spread of bacteria in a macrophage cell line. The first step in …

Listeria monocytogenes insertion mutants defective in hemolysin production were generated
using the conjugative transposons Tn916 and Tn1545. All of the nonhemolytic mutants (hly-…

Listeriolysin O (LLO) is a pore-forming cytolysin that enables Listeria monocytogenes to escape
from a host cell vacuole. The structural gene for the related cytolysin perfringolysin O (pfo…

Intracellular bacterial pathogens, such as Listeria monocytogenes, are detected in the
cytosol of host immune cells. Induction of this host response is often dependent on microbial …

Here we have identified 'triple D' (3d), a recessive N-ethyl-N-nitrosourea-induced mutation
and phenotype in which no signaling occurs via the intracellular Toll-like receptors 3, 7 and 9 (…

A number of technical advances have led to the recent renaissance in the study of L.
monocytogenes. The first was the development of tissue culture models of infection in a variety of …

THE Gram-positive bacterium Listeria monocytogenes is a facultative intracellular pathogen
capable of rapid movement through the host cell cytoplasm 1 . The biophysical basis of the …

Stimulator of interferon genes (STING) is a cytosolic receptor that senses both exogenous
and endogenous cytosolic cyclic dinucleotides (CDNs), activating TBK1/IRF3 (interferon …

Type I interferons (IFNs) are central regulators of the innate and adaptive immune responses
to viral and bacterial infections. Type I IFNs are induced upon cytosolic detection of …