User profiles for Daniel B Roche
 | Daniel B RocheTertiary Knowledge Manager, SOPHiA Genetics Verified email at nespran.com Cited by 1864 |
[HTML][HTML] The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens
Background The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global,
community-driven effort to evaluate and improve the computational annotation of protein …
community-driven effort to evaluate and improve the computational annotation of protein …
DisProt 7.0: a major update of the database of disordered proteins
The Database of Protein Disorder (DisProt, URL: www.disprot.org ) has been significantly
updated and upgraded since its last major renewal in 2007. The current release holds …
updated and upgraded since its last major renewal in 2007. The current release holds …
IntFOLD: an integrated server for modelling protein structures and functions from amino acid sequences
IntFOLD is an independent web server that integrates our leading methods for structure and
function prediction. The server provides a simple unified interface that aims to make …
function prediction. The server provides a simple unified interface that aims to make …
The ModFOLD4 server for the quality assessment of 3D protein models
LJ McGuffin, MT Buenavista, DB Roche - Nucleic acids research, 2013 - academic.oup.com
Once you have generated a 3D model of a protein, how do you know whether it bears any
resemblance to the actual structure? To determine the usefulness of 3D models of proteins, …
resemblance to the actual structure? To determine the usefulness of 3D models of proteins, …
The IntFOLD server: an integrated web resource for protein fold recognition, 3D model quality assessment, intrinsic disorder prediction, domain prediction and ligand …
DB Roche, MT Buenavista, SJ Tetchner… - Nucleic acids …, 2011 - academic.oup.com
The IntFOLD server is a novel independent server that integrates several cutting edge methods
for the prediction of structure and function from sequence. Our guiding principles behind …
for the prediction of structure and function from sequence. Our guiding principles behind …
Rapid model quality assessment for protein structure predictions using the comparison of multiple models without structural alignments
LJ McGuffin, DB Roche - Bioinformatics, 2010 - academic.oup.com
Motivation: The accurate prediction of the quality of 3D models is a key component of
successful protein tertiary structure prediction methods. Currently, clustering- or consensus-based …
successful protein tertiary structure prediction methods. Currently, clustering- or consensus-based …
[HTML][HTML] FunFOLD: an improved automated method for the prediction of ligand binding residues using 3D models of proteins
Background The accurate prediction of ligand binding residues from amino acid sequences
is important for the automated functional annotation of novel proteins. In the previous two …
is important for the automated functional annotation of novel proteins. In the previous two …
Accurate template‐based modeling in CASP12 using the IntFOLD4‐TS, ModFOLD6, and ReFOLD methods
Our aim in CASP12 was to improve our Template‐Based Modeling (TBM) methods through
better model selection, accuracy self‐estimate (ASE) scores and refinement. To meet this aim…
better model selection, accuracy self‐estimate (ASE) scores and refinement. To meet this aim…
The FunFOLD2 server for the prediction of protein–ligand interactions
DB Roche, MT Buenavista, LJ McGuffin - Nucleic acids research, 2013 - academic.oup.com
The FunFOLD2 server is a new independent server that integrates our novel protein–ligand
binding site and quality assessment protocols for the prediction of protein function (FN) from …
binding site and quality assessment protocols for the prediction of protein function (FN) from …
Improvement of 3D protein models using multiple templates guided by single-template model quality assessment
MT Buenavista, DB Roche, LJ McGuffin - Bioinformatics, 2012 - academic.oup.com
Motivation: Modelling the 3D structures of proteins can often be enhanced if more than one
fold template is used during the modelling process. However, in many cases, this may also …
fold template is used during the modelling process. However, in many cases, this may also …