[HTML][HTML] Development of the human infant intestinal microbiota

C Palmer, EM Bik, DB DiGiulio, DA Relman… - PLoS …, 2007 - journals.plos.org
Almost immediately after a human being is born, so too is a new microbial ecosystem, one
that resides in that person's gastrointestinal tract. Although it is a universal and integral part of …

Temporal and spatial variation of the human microbiota during pregnancy

DB DiGiulio, BJ Callahan… - Proceedings of the …, 2015 - National Acad Sciences
Despite the critical role of the human microbiota in health, our understanding of microbiota
compositional dynamics during and after pregnancy is incomplete. We conducted a case-…

[HTML][HTML] Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: a molecular and culture-based investigation

DB DiGiulio, R Romero, HP Amogan, JP Kusanovic… - PloS one, 2008 - journals.plos.org
Background Preterm delivery causes substantial neonatal mortality and morbidity.
Unrecognized intra-amniotic infections caused by cultivation-resistant microbes may play a role. …

Prevalence and diversity of microbes in the amniotic fluid, the fetal inflammatory response, and pregnancy outcome in women with preterm pre‐labor rupture of …

DB DiGiulio, R Romero, JP Kusanovic… - American journal of …, 2010 - Wiley Online Library
… 5, Panel B). Subjects with a negative amniotic fluid culture but positive PCR delivered at an
earlier median gestational age than … Panel B presents results for gestational age at delivery. …

Diversity of microbes in amniotic fluid

DB DiGiulio - Seminars in fetal and neonatal medicine, 2012 - Elsevier
Recent polymerase chain reaction (PCR)-based studies estimate the prevalence of
microbial invasion of the amniotic cavity (MIAC) to be ≥30–50% higher than that detected by …

Replication and refinement of a vaginal microbial signature of preterm birth in two racially distinct cohorts of US women

BJ Callahan, DB DiGiulio… - Proceedings of the …, 2017 - National Acad Sciences
Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality. Previous studies
have suggested that the maternal vaginal microbiota contributes to the pathophysiology of …

A microbial perspective of human developmental biology

MR Charbonneau, LV Blanton, DB DiGiulio… - Nature, 2016 - nature.com
When most people think of human development, they tend to consider only human cells and
organs. Yet there is another facet that involves human-associated microbial communities. A …

Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy

…, DB DiGiulio, K Contrepois, B Callahan… - …, 2019 - academic.oup.com
Motivation Multiple biological clocks govern a healthy pregnancy. These biological mechanisms
produce immunologic, metabolomic, proteomic, genomic and microbiomic adaptations …

Metagenomic analysis with strain-level resolution reveals fine-scale variation in the human pregnancy microbiome

…, CL Sun, DM Proctor, DB DiGiulio… - Genome …, 2018 - genome.cshlp.org
Recent studies suggest that the microbiome has an impact on gestational health and outcome.
However, characterization of the pregnancy-associated microbiome has largely relied on …

Human monkeypox: an emerging zoonosis

DB Di Giulio, PB Eckburg - The Lancet infectious diseases, 2004 - thelancet.com
Early investigations characterised the differences between MPV and variola virus on the basis
of their ability to grow in cell culture and induce death of chick embryos. 4 MPV was also …