Asthma is a common disease with a complex risk architecture including both genetic and
environmental factors. We performed a meta-analysis of North American genome-wide …

The repair outcomes at site-specific DNA double-strand breaks (DSBs) generated by the
RNA-guided DNA endonuclease Cas9 determine how gene function is altered. Despite the …

Cancer gene discovery has relied extensively on analyzing tumors for gains and losses to
reveal the location of oncogenes and tumor suppressor genes, respectively. Deletions of 1p36 …

RNA-guided CRISPR–Cas9 endonucleases are widely used for genome engineering, but
our understanding of Cas9 specificity remains incomplete. Here, we developed a biochemical …

The genomes of multicellular organisms are extensively folded into 3D chromosome territories
within the nucleus 1 . Advanced 3D genome-mapping methods that combine proximity …

Repair of a chromosomal double-strand break (DSB) by gene conversion depends on the
ability of the broken ends to encounter a donor sequence. To understand how chromosomal …

Common variation in over 100 genes has been implicated in the risk of developing asthma,
but the contribution of rare variants to asthma susceptibility remains largely unexplored. We …

The spatial organization of the genome influences cellular function, notably gene regulation.
Recent studies have assessed the three-dimensional (3D) co-localization of functional …

BACKGROUND: Genetic variants that contribute to asthma susceptibility might be present at
varying frequencies in different populations, which is an important consideration and …

It is widely recognized that the three-dimensional (3D) architecture of eukaryotic chromatin
plays an important role in processes such as gene regulation and cancer-driving gene fusions…