Autophagy controls mesenchymal stem cell properties and senescence during bone aging

Y Ma, M Qi, Y An, L Zhang, R Yang, DH Doro, W Liu… - Aging cell, 2018 - Wiley Online Library
Bone marrow‐derived mesenchymal stem cells ( BMMSC s) exhibit degenerative changes,
including imbalanced differentiation and reduced proliferation during aging, that contribute to …

Wnt-modified materials mediate asymmetric stem cell division to direct human osteogenic tissue formation for bone repair

Y Okuchi, J Reeves, SS Ng, DH Doro, S Junyent… - Nature materials, 2021 - nature.com
The maintenance of human skeletal stem cells (hSSCs) and their progeny in bone defects is
a major challenge. Here, we report on a transplantable bandage containing a three-…

[HTML][HTML] Calvarial suture-derived stem cells and their contribution to cranial bone repair

DH Doro, AE Grigoriadis, KJ Liu - Frontiers in Physiology, 2017 - frontiersin.org
In addition to the natural turnover during life, the bones in the skeleton possess the ability to
self-repair in response to injury or disease-related bone loss. Based on studies of bone …

[HTML][HTML] Promotion of neutralizing antibody-independent immunity to wild-type and SARS-CoV-2 variants of concern using an RBD-Nucleocapsid fusion protein

…, R Magalhães, B Cassaro, G Burle, D Doro… - Nature …, 2022 - nature.com
Both T cells and B cells have been shown to be generated after infection with SARS-CoV-2
yet protocols or experimental models to study one or the other are less common. Here, we …

[HTML][HTML] Improved canine and human visceral leishmaniasis immunodiagnosis using combinations of synthetic peptides in enzyme-linked immunosorbent assay

…, M Penido, MS Dos Santos, D Doro… - PLoS Neglected …, 2012 - journals.plos.org
Background Zoonotic visceral leishmaniasis (VL) is a severe infectious disease caused by
protozoan parasites of the genus Leishmania and the domestic dogs are the main urban …

[HTML][HTML] Differential requirement of neutralizing antibodies and T cells on protective immunity to SARS-CoV-2 variants of concern

…, ER Oliveira, MM Figueiredo, AF Carvalho, D Doro… - npj Vaccines, 2023 - nature.com
The current COVID-19 vaccines protect against severe disease, but are not effective in
controlling replication of the Variants of Concern (VOCs). Here, we used the existing pre-clinical …

[HTML][HTML] Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus

…, AM Lopez Muñoz, D Doro… - Nature …, 2018 - nature.com
Neural crest migration is critical to its physiological function. Mechanisms controlling mammalian
neural crest migration are comparatively unknown, due to difficulties accessing this cell …

[HTML][HTML] The osteogenic potential of the neural crest lineage may contribute to craniosynostosis

D Doro, A Liu, AE Grigoriadis, KJ Liu - Molecular syndromology, 2019 - karger.com
The craniofacial skeleton is formed from the neural crest and mesodermal lineages, both of
which contribute mesenchymal precursors during formation of the skull bones. The large …

[HTML][HTML] Cranial suture lineage and contributions to repair of the mouse skull

D Doro, A Liu, JS Lau, AK Rajendran, C Healy… - …, 2024 - journals.biologists.com
The cranial sutures are proposed to be a stem cell niche, harbouring skeletal stem cells that
are directly involved in development, homeostasis and healing. Like the craniofacial bones, …

[HTML][HTML] New Vaccine Formulations Containing a Modified Version of the Amastigote 2 Antigen and the Non-Virulent Trypanosoma cruzi CL-14 Strain Are Highly Antigenic and …

APMM Almeida, LFM Machado, D Doro… - Frontiers in …, 2018 - frontiersin.org
Visceral leishmaniasis (VL) is a major public health issue reported as the second illness in
mortality among all tropical diseases. Clinical trials have shown that protection against VL is …