In the macronuclear rRNA genes of Tetrahymena thermophila, a 413 bp intervening sequence
(IVS) interrupts the 26s rRNA-coding region. A restriction fragment of the rDNA containing …

S. cerevisiae chromosomes end with the telomeric repeat (TG,-&. When any of four Pol II
genes was placed immediately adjacent to the telomeric repeats, expression of the gene was …

DOT1 was originally identified as a gene affecting telomeric silencing in S. cerevisiae. We
now find that Dot1p methylates histone H3 on lysine 79, which maps to the top and bottom of …

Genes placed near telomeres in S. cerevisiae succumb to position-effect variegation. SIR2,
SlR3, SIR4, NATl, ARD7, and HHF2 (histone H4) were identified as modifiers of the position …

… Renauld and DE Gottschling, unpublished results. TLC1 was mapped by hybridizing the
labeled cDNA clone (1.25 kb Xho … This work is dedicated to the memory of Nina Gottschling. …

The covalent modification of nucleosomal histones has emerged as a major determinant of
chromatin structure and gene activity. To understand the interplay between various histone …

The ends of chromosomes in Saccharomyces cerevisiae initiate a repressive chromatin
structure that spreads internally and inhibits the transcription of nearby genes, a phenomenon …

We have isolated the predominant cytoplasmic histone acetyltransferase activity from
Saccharomyces cerevisiae. This enzyme acetylates the lysine at residue 12 of free histone H4 but …

Mitochondria have a central role in ageing. They are considered to be both a target of the
ageing process and a contributor to it 1 . Alterations in mitochondrial structure and function are …

Recent advances in DNA synthesis technology have enabled the construction of novel
genetic pathways and genomic elements, furthering our understanding of system-level …