User profiles for Daniel G. S. Capelluto

Daniel Capelluto

Associate Professor of Biological Sciences, Virginia Tech
Verified email at vt.edu
Cited by 2105

[HTML][HTML] Tollip: a multitasking protein in innate immunity and protein trafficking

DGS Capelluto - Microbes and infection, 2012 - Elsevier
The Toll-interacting protein (Tollip) is a critical regulator of Toll-like receptor (TLR)-mediated
innate immune responses. Tollip modulates TLR signaling and membrane trafficking …

[HTML][HTML] External lipid PI3P mediates entry of eukaryotic pathogen effectors into plant and animal host cells

SD Kale, B Gu, DGS Capelluto, D Dou, E Feldman… - Cell, 2010 - cell.com
Pathogens of plants and animals produce effector proteins that are transferred into the
cytoplasm of host cells to suppress host defenses. One type of plant pathogens, oomycetes, …

Disabled‐2: A modular scaffold protein with multifaceted functions in signaling

CV Finkielstein, DGS Capelluto - Bioessays, 2016 - Wiley Online Library
Disabled‐2 (Dab2) is a multimodular scaffold protein with signaling roles in the domains of
cell growth, trafficking, differentiation, and homeostasis. Emerging evidences place Dab2 as …

The enigmatic role of sulfatides: new insights into cellular functions and mechanisms of protein recognition

S Xiao, CV Finkielstein, DGS Capelluto - Lipid-mediated Protein Signaling, 2013 - Springer
Sulfatides are sphingolipids commonly found at the surface of most of eukaryotic cells.
Sulfatides are not just structural components of the plasma membrane but also participate in a …

The DIX domain targets dishevelled to actin stress fibres and vesicular membranes

DGS Capelluto, TG Kutateladze, R Habas… - Nature, 2002 - nature.com
Colorectal cancer results from mutations in components of the Wnt pathway that regulate β-catenin
levels 1 . Dishevelled (Dvl or Dsh) signals downstream of Wnt receptors and …

Molecular mechanisms responsible for the selective and low-grade induction of proinflammatory mediators in murine macrophages by lipopolysaccharide

…, H Deng, T Glaros, B Baker, DGS Capelluto… - The Journal of …, 2012 - journals.aai.org
Low-dose endotoxemia is prevalent in humans with adverse health conditions, and it
correlates with the pathogenesis of chronic inflammatory diseases such as atherosclerosis, …

A novel heme-regulatory motif mediates heme-dependent degradation of the circadian factor period 2

…, CS Santos, SP Mury, DGS Capelluto… - … and cellular biology, 2008 - Taylor & Francis
Although efforts have been made to identify circadian-controlled genes regulating cell cycle
progression and cell death, little is known about the metabolic signals modulating circadian …

[HTML][HTML] Chronotherapy: intuitive, sound, founded… but not broadly applied

…, S Schiffhauer, JJ Liu, PE Stauffer, A Li, DGS Capelluto… - Drugs, 2016 - Springer
Circadian rhythms are a collection of endogenously driven biochemical, physiological, and
behavioral processes that oscillate in a 24-h cycle and can be entrained by external cues. …

Structural Basis for Interactions of the Phytophthora sojae RxLR Effector Avh5 with Phosphatidylinositol 3-Phosphate and for Host Cell Entry

…, D Li, BM Tyler, DGS Capelluto - Molecular Plant …, 2013 - Am Phytopath Society
Oomycetes such as Phytophthora sojae employ effector proteins that enter plant cells to facilitate
infection. Entry of some effector proteins is mediated by RxLR motifs in the effectors and …

[HTML][HTML] Multivalent mechanism of membrane insertion by the FYVE domain

TG Kutateladze, DGS Capelluto, CG Ferguson… - Journal of Biological …, 2004 - ASBMB
Targeting of a wide variety of proteins to membranes involves specific recognition of phospholipid
head groups and insertion into lipid bilayers. For example, proteins that contain FYVE …