<p id="p001">Mutations of the epidermal growth factor receptor (<italic>EGFR</italic>) gene
have been identified in specimens from patients with non–small-cell lung cancer who have …

Because this is the first large cohort study on this topic, our report will provide much-needed
information that will benefit patients with cancer globally. As such, we believe it is extremely …

Transcription factors are master regulatory switches of differentiation, including the
development of specific hematopoietic lineages from stem cells. Here we show that mice with …

The transcription factor C/EBPα (for CCAAT/enhancer binding protein-α; encoded by the
gene CEBPA) is crucial for the differentiation of granulocytes. Conditional expression of C/EBPα …

Tumor-infiltrating myeloid cells (TIMs) comprise monocytes, macrophages, dendritic cells,
and neutrophils, and have emerged as key regulators of cancer growth. These cells can …

Our understanding of myeloid factors has been brought about we will focus on how alteration
of myeloid transcription by a number of different methods. Initially, myeloid factors were …

Although much is understood about the ways in which transcription factors regulate various
differentiation systems, and one of the hallmarks of many human cancers is a lack of cellular …

In recent years, great progress has been made in elucidating the progenitor-cell hierarchy
of the myeloid lineage. Transcription factors have been shown to be key determinants in the …

The transcription factor C/EBPα is required for granulopoiesis and frequently disrupted in
human acute myeloid leukemia (AML). Here, we show disruption of C/EBPα blocks the …

The transcription factor CCAAT/enhancer binding protein α (C/EBPα) regulates a number of
myeloid cell-specific genes. To delineate the role of C/EBPα in human granulopoiesis, we …