CRISPR (clustered regularly interspaced short palindromic repeats) arrays and their
associated (Cas) proteins confer bacteria and archaea adaptive immunity against exogenous …

Rfam is a database of RNA families where each of the 3444 families is represented by a
multiple sequence alignment of known RNA sequences and a covariance model that can be …

The formation of mature mRNAs in vertebrates involves the cleavage and polyadenylation
of the pre-mRNA, 10–30 nt downstream of an AAUAAA or AUUAAA signal sequence. The …

RNA molecules fold into characteristic secondary and tertiary structures that account for their
diverse functional activities. Many of these RNA structures are assembled from a collection …

We present here a new approach to the problem of defining RNA signatures and finding
their occurrences in sequence databases. The proposed method is based on “secondary …

Background The dung-inhabiting ascomycete fungus Podospora anserina is a model used
to study various aspects of eukaryotic and fungal biology, such as ageing, prions and sexual …

Rho-independent termination is a major mechanism of transcriptional arrest in bacteria that
controls both normal 3’ termination and a wide array of regulatory attenuation events. …

Appropriate cancer care requires a thorough understanding of the natural history of the
disease, including the cell of origin, the pattern of clonal evolution, and the functional …

Selenocysteine is incorporated into selenoproteins by an in-frame UGA codon whose
readthrough requires the selenocysteine insertion sequence (SECIS), a conserved hairpin in the 3…

Using an experimental approach, we investigated the RNome of the pathogen Staphylococcus
aureus to identify 30 small RNAs (sRNAs) including 14 that are newly confirmed. Among …