The generation of cell-mediated immunity against many infectious pathogens involves the
production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many …

Infection with any 1 of 4 dengue viruses produces a spectrum of clinical illness ranging from
a mild undifferentiated febrile illness to dengue fever (DF) to dengue hemorrhagic fever (…

Dengue hemorrhagic fever (DHF), the most severe form of illness following infection with a
dengue virus, is characterized by plasma leakage, thrombocytopenia, and hepatic …

Dengue viruses are a major cause of morbidity in tropical and subtropical regions of the
world. Knowledge about the epidemiology and host determinants of inapparent and severe …

Background. Infection with any 1 of the 4 dengue viruses (DVs) can produce several illnesses,
ranging from a mild febrile illness to classic dengue fever (DF) to dengue hemorrhagic …

Little is known of the role of classical HLA‐A and ‐B class I alleles in determining resistance,
susceptibility, or the severity of acute viral infections. Appropriate paradigms for …

Background Transmission of dengue viruses (DENV), the leading cause of arboviral disease
worldwide, is known to vary through time and space, likely owing to a combination of …

Background Dengue viruses are a major cause of morbidity in tropical and subtropical
regions of the world. Inapparent dengue is an important component of the overall burden of …

The ability of dendritic cells (DCs) to shape the adaptive immune response to viral infection
is mediated largely by their maturation and activation state as determined by the surface …

Background: Although plasma leakage is the major cause of mortality and morbidity in patients
with dengue hemorrhagic fever (DHF), a detailed assessment of the natural course of this …