The first component known to recognize and discriminate among potential 5′ splice sites (5′SSs)
in pre-mRNA is the U1 snRNP. However, the relative levels of U1 snRNP binding to …

Aneuploidy and chromosome instability are common abnormalities in human cancer. Loss
of control over mitotic progression, multipolar spindle formation, and cytokinesis defects are …

Aneuploidy and chromosome instability are two of the most common abnormalities in
cancer cells. They arise through defects in cell division and, specifically, in the unequal …

Objectives: To determine the contemporary prevalence of and mortality in patients with
coronary artery disease (CAD) not amenable to revascularization. Background: A growing …

The spindle assembly checkpoint (SAC) ensures proper chromosome segregation by delaying
anaphase onset in response to unattached kinetochores. Checkpoint signalling requires …

Chromatin‐associated proteins are essential for the specification and maintenance of cell
identity. They exert these functions through modulating and maintaining transcriptional patterns…

The mitotic spindle is defined by its organized, bipolar mass of microtubules, which drive
chromosome alignment and segregation. Although different cells have been shown to use …

Cyclin B–dependent kinase (CDK1-CCNB1) promotes entry into mitosis. Additionally, it
inhibits mitotic exit by activating the spindle checkpoint. This latter role is mediated through …

Purpose The purpose of this study was to assess the diagnostic accuracy of 18F-fluorodeoxyglucose
with positron emission tomography and computed tomography (FDG–PET–CT) to …

In mitosis, the spindle assembly checkpoint (SAC) monitors the formation of microtubule‐kinetochore
attachments during capture of chromosomes by the mitotic spindle. Spindle …